Prognostic value or 18-FDG uptake in early stage NSCLC

J. C. Chen, T. W. Huang, Y. L. Cheng, H. Chang, C. Tzao, W. S. Huang, S. C. Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: We assessed whether the standard uptake of 18- fluorodeoxyglucose (18-FDG) in non-small cell lung cancers (NSCLC) differed between stage I and non-stage 1 tumors, Methods: We reviewed 163 patients with NSCLC who underwent surgical lymph node dissection after tumor resection in 2002-2003, Patients with clinical stage INSCLC who were investigated with preoperative positron emission tomography integrated computed tomography (PET-CT) scans using 18-FDG uptake were included; those with N2 disease were excluded, We reviewed 55 patients with a mean follow-up of 68 months. Results: We analyzed 36 patients with stage I (Group 1 ) and 19 patients with non-stage INSCLC (Group 2; 8 stage II, 7 stage III and 4 stage IV). There were no statistical differences in sex, age, tumor size, histological type, location or tumor differentiation between the groups, Group 1 had lower maximum standard 18-FDG uptake values (SUVmax) than Group 2 (4.9 ±2.7 vs. 8.1 ±3.8; P =0.001), Using multiple logistic regression, patients with higher preoperative SUVmax and serum carcinoembryonic antigen (CEA) levels showed advanced tumor stages postoperatively (SUVmax > 4.7, odds ratio 7,65; CEA > 3.5 ng/mL, odds ratio 8.39). High 18-FDG uptake was significantly associated with reduced median survival (62.69 months for SUVmax 4,7). Conclusions: High preoperative 18-FDG uptake of tumors was significantly associated with reduced overall patient survival. The SUVmax of the tumor and serum CEA levels demonstrated aggressive tumors and could be helpful preoperatively when considering patients for induction therapy or resection.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalThoracic and Cardiovascular Surgeon
Volume57
Issue number7
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Carcinoembryonic Antigen
Neoplasms
Odds Ratio
Survival
Lymph Node Excision
Serum
Sex Characteristics
Logistic Models

Keywords

  • NSCLC
  • PET-CT
  • SUV
  • Thoracic surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Chen, J. C., Huang, T. W., Cheng, Y. L., Chang, H., Tzao, C., Huang, W. S., & Lee, S. C. (2009). Prognostic value or 18-FDG uptake in early stage NSCLC. Thoracic and Cardiovascular Surgeon, 57(7), 413-416. https://doi.org/10.1055/s-0029-1185733

Prognostic value or 18-FDG uptake in early stage NSCLC. / Chen, J. C.; Huang, T. W.; Cheng, Y. L.; Chang, H.; Tzao, C.; Huang, W. S.; Lee, S. C.

In: Thoracic and Cardiovascular Surgeon, Vol. 57, No. 7, 2009, p. 413-416.

Research output: Contribution to journalArticle

Chen, JC, Huang, TW, Cheng, YL, Chang, H, Tzao, C, Huang, WS & Lee, SC 2009, 'Prognostic value or 18-FDG uptake in early stage NSCLC', Thoracic and Cardiovascular Surgeon, vol. 57, no. 7, pp. 413-416. https://doi.org/10.1055/s-0029-1185733
Chen, J. C. ; Huang, T. W. ; Cheng, Y. L. ; Chang, H. ; Tzao, C. ; Huang, W. S. ; Lee, S. C. / Prognostic value or 18-FDG uptake in early stage NSCLC. In: Thoracic and Cardiovascular Surgeon. 2009 ; Vol. 57, No. 7. pp. 413-416.
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AU - Huang, W. S.

AU - Lee, S. C.

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N2 - Background: We assessed whether the standard uptake of 18- fluorodeoxyglucose (18-FDG) in non-small cell lung cancers (NSCLC) differed between stage I and non-stage 1 tumors, Methods: We reviewed 163 patients with NSCLC who underwent surgical lymph node dissection after tumor resection in 2002-2003, Patients with clinical stage INSCLC who were investigated with preoperative positron emission tomography integrated computed tomography (PET-CT) scans using 18-FDG uptake were included; those with N2 disease were excluded, We reviewed 55 patients with a mean follow-up of 68 months. Results: We analyzed 36 patients with stage I (Group 1 ) and 19 patients with non-stage INSCLC (Group 2; 8 stage II, 7 stage III and 4 stage IV). There were no statistical differences in sex, age, tumor size, histological type, location or tumor differentiation between the groups, Group 1 had lower maximum standard 18-FDG uptake values (SUVmax) than Group 2 (4.9 ±2.7 vs. 8.1 ±3.8; P =0.001), Using multiple logistic regression, patients with higher preoperative SUVmax and serum carcinoembryonic antigen (CEA) levels showed advanced tumor stages postoperatively (SUVmax > 4.7, odds ratio 7,65; CEA > 3.5 ng/mL, odds ratio 8.39). High 18-FDG uptake was significantly associated with reduced median survival (62.69 months for SUVmax 4,7). Conclusions: High preoperative 18-FDG uptake of tumors was significantly associated with reduced overall patient survival. The SUVmax of the tumor and serum CEA levels demonstrated aggressive tumors and could be helpful preoperatively when considering patients for induction therapy or resection.

AB - Background: We assessed whether the standard uptake of 18- fluorodeoxyglucose (18-FDG) in non-small cell lung cancers (NSCLC) differed between stage I and non-stage 1 tumors, Methods: We reviewed 163 patients with NSCLC who underwent surgical lymph node dissection after tumor resection in 2002-2003, Patients with clinical stage INSCLC who were investigated with preoperative positron emission tomography integrated computed tomography (PET-CT) scans using 18-FDG uptake were included; those with N2 disease were excluded, We reviewed 55 patients with a mean follow-up of 68 months. Results: We analyzed 36 patients with stage I (Group 1 ) and 19 patients with non-stage INSCLC (Group 2; 8 stage II, 7 stage III and 4 stage IV). There were no statistical differences in sex, age, tumor size, histological type, location or tumor differentiation between the groups, Group 1 had lower maximum standard 18-FDG uptake values (SUVmax) than Group 2 (4.9 ±2.7 vs. 8.1 ±3.8; P =0.001), Using multiple logistic regression, patients with higher preoperative SUVmax and serum carcinoembryonic antigen (CEA) levels showed advanced tumor stages postoperatively (SUVmax > 4.7, odds ratio 7,65; CEA > 3.5 ng/mL, odds ratio 8.39). High 18-FDG uptake was significantly associated with reduced median survival (62.69 months for SUVmax 4,7). Conclusions: High preoperative 18-FDG uptake of tumors was significantly associated with reduced overall patient survival. The SUVmax of the tumor and serum CEA levels demonstrated aggressive tumors and could be helpful preoperatively when considering patients for induction therapy or resection.

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