Prognostic value of electrocorticography findings during callosotomy in children with Lennox - Gastaut syndrome

Shang Yeong Kwan, Ji Ho Lin, Tai-Tong Wong, Kai Ping Chang, Chun Hing Yiu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: To analyze findings and acute changes in electrocorticograms (ECoGs) obtained during corpus callosotomy in order to identify any relationships with the postoperative outcome of seizure activity. Methods: We retrospectively analyzed ECoGs obtained during anterior callosotomy (4-6 cm) in 48 patients with Lennox-Gastaut syndrome (32 boys and 16 girls, age 1-20 years, mean age 7.6 years) who underwent surgery between July 1993 and November 1996 to correlate recording findings with postoperative seizure activity. At the time of analysis, all patients had been followed postoperatively for more than 4 years. Results: Of 48 patients, 31 (64.6%) had significant improvement in seizure control after surgery. In pre-excisional ECoGs, 38 (79.2%) of 48 patients had bisynchronous epileptiform discharges. Patients (23 of 33 patients, 69.7%) with significant blockage of bisynchronous discharges recorded during callosotomy achieved the best postoperative seizure outcomes, but the difference did not reach statistical significance (P > 0.05). Conclusions: Based on our experience, changes in ECoG during callosotomy do not predict postoperative seizure outcome. Insignificant blockage of bisynchronous epileptiform discharges in ECoGs during callosotomy does not predict a worse prognosis than that associated with significant intraoperative blockage.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalSeizure
Volume14
Issue number7
DOIs
Publication statusPublished - Oct 1 2005
Externally publishedYes

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Seizures
Electrocorticography
Lennox Gastaut Syndrome

Keywords

  • Callosotomy
  • Corpus callosum
  • ECoG
  • Electrocorticogram
  • Epilepsy
  • Lennox-Gastaut syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Prognostic value of electrocorticography findings during callosotomy in children with Lennox - Gastaut syndrome. / Kwan, Shang Yeong; Lin, Ji Ho; Wong, Tai-Tong; Chang, Kai Ping; Yiu, Chun Hing.

In: Seizure, Vol. 14, No. 7, 01.10.2005, p. 470-475.

Research output: Contribution to journalArticle

Kwan, Shang Yeong ; Lin, Ji Ho ; Wong, Tai-Tong ; Chang, Kai Ping ; Yiu, Chun Hing. / Prognostic value of electrocorticography findings during callosotomy in children with Lennox - Gastaut syndrome. In: Seizure. 2005 ; Vol. 14, No. 7. pp. 470-475.
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AB - Objectives: To analyze findings and acute changes in electrocorticograms (ECoGs) obtained during corpus callosotomy in order to identify any relationships with the postoperative outcome of seizure activity. Methods: We retrospectively analyzed ECoGs obtained during anterior callosotomy (4-6 cm) in 48 patients with Lennox-Gastaut syndrome (32 boys and 16 girls, age 1-20 years, mean age 7.6 years) who underwent surgery between July 1993 and November 1996 to correlate recording findings with postoperative seizure activity. At the time of analysis, all patients had been followed postoperatively for more than 4 years. Results: Of 48 patients, 31 (64.6%) had significant improvement in seizure control after surgery. In pre-excisional ECoGs, 38 (79.2%) of 48 patients had bisynchronous epileptiform discharges. Patients (23 of 33 patients, 69.7%) with significant blockage of bisynchronous discharges recorded during callosotomy achieved the best postoperative seizure outcomes, but the difference did not reach statistical significance (P > 0.05). Conclusions: Based on our experience, changes in ECoG during callosotomy do not predict postoperative seizure outcome. Insignificant blockage of bisynchronous epileptiform discharges in ECoGs during callosotomy does not predict a worse prognosis than that associated with significant intraoperative blockage.

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