Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer

Wei Chung Hsieh, Ya Wen Cheng, Cuei Iyuan Lin, Ming Chih Chou, Chih Yi Chen, Huei Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: A novel T-77C polymorphism in the promoter region of the DNA repair gene X-ray cross-complementing group 1 (XRCC1) may modulate its transcription to increase the risk of lung cancer. Here, we attempt to clarify: (i) whether the XRCC1 T-77C polymorphism was associated with lung cancer risk in Taiwanese and (ii) whether this polymorphism could act as a prognostic indicator to predict the clinical outcome of non-small-cell lung cancer (NSCLC) patients. Methods: A total of 294 primary lung cancer patients and 288 potential controls were recruited into our study. Clinical data were collected. The genotypes of XRCC1 T-77C were identified by polymerase chain reaction. Results: Our case-control study showed that the XRCC1 T-77C polymorphism was not associated with the risk of lung cancer in Taiwanese patients. To verify the impact of the XRCC1 T-77C polymorphism on the clinical outcome of NSCLC, survival analysis showed that patients with TT had a lower survival rate than those with the TC + CC genotype (33.1% versus 48.8%, P = 0.031). The Cox regression analysis further indicated that patients with the TT genotype had a 1.84-fold risk compared with those with the TC + CC genotype (95% CI, 1.16-2.86, P = 0.008). Conclusion: Our results suggest that XRCC1 T-77C variants (TC + CC) may act as a favorable prognostic indicator of resected NSCLC.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume39
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • NSCLC
  • Prognosis
  • XRCC1 genetic polymorphism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

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