Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller

H. W. Lai, S. J. Kuo, L. S. Chen, C. W. Chi, S. T. Chen, T. W. Chang, D. R. Chen

Research output: Contribution to journalArticle

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Abstract

Aims: The purpose of this study was to clarify the prognostic significance of triple-negative breast cancer (TNBC) with a tumor size ≤ 1 cm. Materials and methods: Patients with primary operable breast cancer with a tumor size ≤ 1 cm were enrolled at Changhua Christian Hospital and National Cheng-Kung University Hospital. Tumors negative for ER, PR, and HER-2 were classified as TNBCs and compared with tumors with any receptor positivity (non-TNBC) for disease-free survival (DFS) and cancer-specific survival (CSS). Results: From 1995 to 2006, a total of 377 patients with tumor size ≤ 1 cm were enrolled. Compared with non-TNBC patients, TNBC patients with a tumor size ≤ 1 cm as a whole or in a lymph node-positive subgroup were not associated with a poorer 5-year DFS and CSS. In lymph node-negative patients (pT1a-bN0M0), TNBC was associated with a poorer 5-year CSS but not DFS. Compared with the hormone receptor-positive, HER-2-negative subgroup, TNBC was associated with poorer DFS and CSS. In the multivariate Cox regression hazard analysis, lymph node invasion was the most important cause of disease recurrence and cancer-specific death. Conclusion: TNBC is very likely an independent risk factor in small (≤1 cm) node-negative invasive breast cancer. With tumors 1 cm and smaller, lymph node invasion was the single most important prognostic factor.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Triple Negative Breast Neoplasms
Neoplasms
Disease-Free Survival
Lymph Nodes
Breast Neoplasms
Survival
Breast Diseases

Keywords

  • Estrogen receptor
  • HER-2
  • Progesterone receptor
  • Triple-negative breast cancer
  • Tumor size

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller. / Lai, H. W.; Kuo, S. J.; Chen, L. S.; Chi, C. W.; Chen, S. T.; Chang, T. W.; Chen, D. R.

In: European Journal of Surgical Oncology, Vol. 37, No. 1, 01.2011, p. 18-24.

Research output: Contribution to journalArticle

Lai, H. W. ; Kuo, S. J. ; Chen, L. S. ; Chi, C. W. ; Chen, S. T. ; Chang, T. W. ; Chen, D. R. / Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller. In: European Journal of Surgical Oncology. 2011 ; Vol. 37, No. 1. pp. 18-24.
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AB - Aims: The purpose of this study was to clarify the prognostic significance of triple-negative breast cancer (TNBC) with a tumor size ≤ 1 cm. Materials and methods: Patients with primary operable breast cancer with a tumor size ≤ 1 cm were enrolled at Changhua Christian Hospital and National Cheng-Kung University Hospital. Tumors negative for ER, PR, and HER-2 were classified as TNBCs and compared with tumors with any receptor positivity (non-TNBC) for disease-free survival (DFS) and cancer-specific survival (CSS). Results: From 1995 to 2006, a total of 377 patients with tumor size ≤ 1 cm were enrolled. Compared with non-TNBC patients, TNBC patients with a tumor size ≤ 1 cm as a whole or in a lymph node-positive subgroup were not associated with a poorer 5-year DFS and CSS. In lymph node-negative patients (pT1a-bN0M0), TNBC was associated with a poorer 5-year CSS but not DFS. Compared with the hormone receptor-positive, HER-2-negative subgroup, TNBC was associated with poorer DFS and CSS. In the multivariate Cox regression hazard analysis, lymph node invasion was the most important cause of disease recurrence and cancer-specific death. Conclusion: TNBC is very likely an independent risk factor in small (≤1 cm) node-negative invasive breast cancer. With tumors 1 cm and smaller, lymph node invasion was the single most important prognostic factor.

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