Prognostic significance of nm23-H1 expression in esophageal squamous cell carcinoma

Liang Shun Wang, Kuan Chih Chow, Yung Chang Lien, Kuang Tai Kuo, Wing Yin Li

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives: Tumor recurrence and metastasis are major causes of treatment failure in esophageal squamous cell carcinoma (ESCC). Recently, nm23, originally considered to be an anti-metastatic gene, has been reported to associate with various roles in different human cancers. We therefore investigated the clinical significance of nm23-H1 expression in ESCC. Methods: Pathological sections were immunohistochemically stained with monoclonal antibody that was specific to nm23-H1. Expression of positive nm23-H1 staining was further confirmed by Western blot and reverse transcription-polymerase chain reaction (RT-PCR). The relationship between nm23-H1 expression and clinicopathological variables was examined by statistical analysis. Except for 11 (7%) surgical morality, the remaining 145 patients entered the prognostic analysis. The cisplatin-based chemotherapy was established for the patients with tumor stages at or beyond IIb, or with tumor recurrence. Survival difference between groups was compared by log rank test. Results: Immunohistochemically, nm23-H1 expression was detected in 39.3% (57/145) of the pathological sections. It was positively correlated with tumor stage (P=0.002), evident lymphovascular invasion (P

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalEuropean Journal of Cardio-thoracic Surgery
Volume26
Issue number2
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Keywords

  • Chemosensitivity
  • Esophageal carcinoma
  • nm23

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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