Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

Tung Bo Chao, Chien Feng Li, Ching Yih Lin, Yu Feng Tian, I. Wei Chang, Ming Jen Sheu, Ying En Lee, Ti Chun Chan, Hong Lin He

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.

Original languageEnglish
Pages (from-to)1457-1467
Number of pages11
JournalFuture Oncology
Volume12
Issue number12
DOIs
Publication statusPublished - Jun 1 2016
Externally publishedYes

Fingerprint

Chemoradiotherapy
Adenocarcinoma
Survival
Rectal Neoplasms
Data Mining
Genes
Immunohistochemistry
Neoplasm Metastasis
Recurrence
Neoplasms

Keywords

  • chemoradiotherapy
  • DSG3
  • rectal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy. / Chao, Tung Bo; Li, Chien Feng; Lin, Ching Yih; Tian, Yu Feng; Chang, I. Wei; Sheu, Ming Jen; Lee, Ying En; Chan, Ti Chun; He, Hong Lin.

In: Future Oncology, Vol. 12, No. 12, 01.06.2016, p. 1457-1467.

Research output: Contribution to journalArticle

Chao, TB, Li, CF, Lin, CY, Tian, YF, Chang, IW, Sheu, MJ, Lee, YE, Chan, TC & He, HL 2016, 'Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy', Future Oncology, vol. 12, no. 12, pp. 1457-1467. https://doi.org/10.2217/fon-2016-0071
Chao, Tung Bo ; Li, Chien Feng ; Lin, Ching Yih ; Tian, Yu Feng ; Chang, I. Wei ; Sheu, Ming Jen ; Lee, Ying En ; Chan, Ti Chun ; He, Hong Lin. / Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy. In: Future Oncology. 2016 ; Vol. 12, No. 12. pp. 1457-1467.
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abstract = "Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.",
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AU - Sheu, Ming Jen

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