Prognostic significance of computed tomography scan-derived splenic volume in hepatocellular carcinoma treated with radiofrequency ablation

Wen Chieh Wu, Yi You Chiou, Hung Hsu Hung, Wei Yu Kao, Yi Hong Chou, Chien Wei Su, Jaw Ching Wu, Teh Ia Huo, Yi Hsiang Huang, Kuei Chuan Lee, Han Chieh Lin, Shou Dong Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

GOALS: To evaluate the clinical implication of splenic volume measured by computed tomography (CT) scan in hepatocellular carcinoma (HCC) patients undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND: Splenomegaly is an important sign of portal hypertension and poor liver function in patients with advanced liver disease. But whether it could predict the prognosis of patients with HCC is still obscure. STUDY: We enrolled 161 treatment-naive HCC patients. Splenomegaly was defined as splenic volume >300 mL by CT scan and its impact on prognosis was analyzed. Moreover, noninvasive serum markers were validated to predict splenomegaly. RESULTS: A total of 78 patients were with splenomegaly, while the remaining 83 patients had normal splenic volume at the time of receiving RFA. After a median follow-up of 38.1±20.8 months, 41 patients died. The cumulative 5-year survival rates were 54.8% and 77.8% in patients with splenomegaly and in those with normal splenic volume, respectively (P=0.003). By multivariate analysis, age 65 years and older, serum albumin levels ≤3.5 g/dL, and splenic volume >300 mL were independent risk factors associated with poor overall survival after RFA. For predicting splenomegaly by noninvasive serum markers, platelet count yielded the highest area under the curve from corresponding receiver operating curves with a level of 0.868 at a cut-off value of 11,7000/mm. CONCLUSIONS: HCC patients with splenomegaly measured by CT scan have relatively poorer liver functional reserve than those with normal splenic volume. Splenomegaly is an independent risk factor predicting overall survival for patients with small HCC undergoing RFA.

Original languageEnglish
Pages (from-to)789-795
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume46
Issue number9
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Fingerprint

Splenomegaly
Hepatocellular Carcinoma
Tomography
Biomarkers
Cone-Beam Computed Tomography
Survival
Liver
Portal Hypertension
Platelet Count
Serum Albumin
Area Under Curve
Liver Diseases
Multivariate Analysis
Survival Rate

Keywords

  • hepatocellular carcinoma
  • liver fibrosis
  • prognosis
  • radiofrequency ablation
  • splenic volume

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prognostic significance of computed tomography scan-derived splenic volume in hepatocellular carcinoma treated with radiofrequency ablation. / Wu, Wen Chieh; Chiou, Yi You; Hung, Hung Hsu; Kao, Wei Yu; Chou, Yi Hong; Su, Chien Wei; Wu, Jaw Ching; Huo, Teh Ia; Huang, Yi Hsiang; Lee, Kuei Chuan; Lin, Han Chieh; Lee, Shou Dong.

In: Journal of Clinical Gastroenterology, Vol. 46, No. 9, 01.10.2012, p. 789-795.

Research output: Contribution to journalArticle

Wu, Wen Chieh ; Chiou, Yi You ; Hung, Hung Hsu ; Kao, Wei Yu ; Chou, Yi Hong ; Su, Chien Wei ; Wu, Jaw Ching ; Huo, Teh Ia ; Huang, Yi Hsiang ; Lee, Kuei Chuan ; Lin, Han Chieh ; Lee, Shou Dong. / Prognostic significance of computed tomography scan-derived splenic volume in hepatocellular carcinoma treated with radiofrequency ablation. In: Journal of Clinical Gastroenterology. 2012 ; Vol. 46, No. 9. pp. 789-795.
@article{bc12735ab42f49518064f2aaa720b700,
title = "Prognostic significance of computed tomography scan-derived splenic volume in hepatocellular carcinoma treated with radiofrequency ablation",
abstract = "GOALS: To evaluate the clinical implication of splenic volume measured by computed tomography (CT) scan in hepatocellular carcinoma (HCC) patients undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND: Splenomegaly is an important sign of portal hypertension and poor liver function in patients with advanced liver disease. But whether it could predict the prognosis of patients with HCC is still obscure. STUDY: We enrolled 161 treatment-naive HCC patients. Splenomegaly was defined as splenic volume >300 mL by CT scan and its impact on prognosis was analyzed. Moreover, noninvasive serum markers were validated to predict splenomegaly. RESULTS: A total of 78 patients were with splenomegaly, while the remaining 83 patients had normal splenic volume at the time of receiving RFA. After a median follow-up of 38.1±20.8 months, 41 patients died. The cumulative 5-year survival rates were 54.8{\%} and 77.8{\%} in patients with splenomegaly and in those with normal splenic volume, respectively (P=0.003). By multivariate analysis, age 65 years and older, serum albumin levels ≤3.5 g/dL, and splenic volume >300 mL were independent risk factors associated with poor overall survival after RFA. For predicting splenomegaly by noninvasive serum markers, platelet count yielded the highest area under the curve from corresponding receiver operating curves with a level of 0.868 at a cut-off value of 11,7000/mm. CONCLUSIONS: HCC patients with splenomegaly measured by CT scan have relatively poorer liver functional reserve than those with normal splenic volume. Splenomegaly is an independent risk factor predicting overall survival for patients with small HCC undergoing RFA.",
keywords = "hepatocellular carcinoma, liver fibrosis, prognosis, radiofrequency ablation, splenic volume",
author = "Wu, {Wen Chieh} and Chiou, {Yi You} and Hung, {Hung Hsu} and Kao, {Wei Yu} and Chou, {Yi Hong} and Su, {Chien Wei} and Wu, {Jaw Ching} and Huo, {Teh Ia} and Huang, {Yi Hsiang} and Lee, {Kuei Chuan} and Lin, {Han Chieh} and Lee, {Shou Dong}",
year = "2012",
month = "10",
day = "1",
doi = "10.1097/MCG.0b013e31825ceeb5",
language = "English",
volume = "46",
pages = "789--795",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Prognostic significance of computed tomography scan-derived splenic volume in hepatocellular carcinoma treated with radiofrequency ablation

AU - Wu, Wen Chieh

AU - Chiou, Yi You

AU - Hung, Hung Hsu

AU - Kao, Wei Yu

AU - Chou, Yi Hong

AU - Su, Chien Wei

AU - Wu, Jaw Ching

AU - Huo, Teh Ia

AU - Huang, Yi Hsiang

AU - Lee, Kuei Chuan

AU - Lin, Han Chieh

AU - Lee, Shou Dong

PY - 2012/10/1

Y1 - 2012/10/1

N2 - GOALS: To evaluate the clinical implication of splenic volume measured by computed tomography (CT) scan in hepatocellular carcinoma (HCC) patients undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND: Splenomegaly is an important sign of portal hypertension and poor liver function in patients with advanced liver disease. But whether it could predict the prognosis of patients with HCC is still obscure. STUDY: We enrolled 161 treatment-naive HCC patients. Splenomegaly was defined as splenic volume >300 mL by CT scan and its impact on prognosis was analyzed. Moreover, noninvasive serum markers were validated to predict splenomegaly. RESULTS: A total of 78 patients were with splenomegaly, while the remaining 83 patients had normal splenic volume at the time of receiving RFA. After a median follow-up of 38.1±20.8 months, 41 patients died. The cumulative 5-year survival rates were 54.8% and 77.8% in patients with splenomegaly and in those with normal splenic volume, respectively (P=0.003). By multivariate analysis, age 65 years and older, serum albumin levels ≤3.5 g/dL, and splenic volume >300 mL were independent risk factors associated with poor overall survival after RFA. For predicting splenomegaly by noninvasive serum markers, platelet count yielded the highest area under the curve from corresponding receiver operating curves with a level of 0.868 at a cut-off value of 11,7000/mm. CONCLUSIONS: HCC patients with splenomegaly measured by CT scan have relatively poorer liver functional reserve than those with normal splenic volume. Splenomegaly is an independent risk factor predicting overall survival for patients with small HCC undergoing RFA.

AB - GOALS: To evaluate the clinical implication of splenic volume measured by computed tomography (CT) scan in hepatocellular carcinoma (HCC) patients undergoing percutaneous radiofrequency ablation (RFA). BACKGROUND: Splenomegaly is an important sign of portal hypertension and poor liver function in patients with advanced liver disease. But whether it could predict the prognosis of patients with HCC is still obscure. STUDY: We enrolled 161 treatment-naive HCC patients. Splenomegaly was defined as splenic volume >300 mL by CT scan and its impact on prognosis was analyzed. Moreover, noninvasive serum markers were validated to predict splenomegaly. RESULTS: A total of 78 patients were with splenomegaly, while the remaining 83 patients had normal splenic volume at the time of receiving RFA. After a median follow-up of 38.1±20.8 months, 41 patients died. The cumulative 5-year survival rates were 54.8% and 77.8% in patients with splenomegaly and in those with normal splenic volume, respectively (P=0.003). By multivariate analysis, age 65 years and older, serum albumin levels ≤3.5 g/dL, and splenic volume >300 mL were independent risk factors associated with poor overall survival after RFA. For predicting splenomegaly by noninvasive serum markers, platelet count yielded the highest area under the curve from corresponding receiver operating curves with a level of 0.868 at a cut-off value of 11,7000/mm. CONCLUSIONS: HCC patients with splenomegaly measured by CT scan have relatively poorer liver functional reserve than those with normal splenic volume. Splenomegaly is an independent risk factor predicting overall survival for patients with small HCC undergoing RFA.

KW - hepatocellular carcinoma

KW - liver fibrosis

KW - prognosis

KW - radiofrequency ablation

KW - splenic volume

UR - http://www.scopus.com/inward/record.url?scp=84866256208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866256208&partnerID=8YFLogxK

U2 - 10.1097/MCG.0b013e31825ceeb5

DO - 10.1097/MCG.0b013e31825ceeb5

M3 - Article

VL - 46

SP - 789

EP - 795

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - 9

ER -