Prognostic significance of β-catenin and topoisomerase IIα in de novo acute myeloid leukemia

Chih G. Chen, Jyh Pyng Gau, Jie Yu You, Kuan Der Lee, An Bin Yu, Chang Hsien Lu, Jen Tsun Lin, Chieh Lan, Wan Hsia Lo, Jacqueline Ming Liu, Ching Fen Yang

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The Wnt/β-catenin signaling is important for controlling self-renewal of hematopoietic stem cells and its constitutive activation has recently been documented in a significant proportion of acute myeloid leukemia (AML) cases. Topoisomerase IIα (Topo IIα) is a marker of cell proliferation and a crucial target for anthracycline cytotoxicity, the mainstay of management employed in AML. We retrospectively investigated the prognostic roles of β-catenin and topo IIα in a cohort of 59 patients with newly diagnosed AML by immunohistochemistry. Aberrant β-catenin expression was demonstrated in 13 patients (22%), and it was more likely to occur in those with unfavorable karyotypes. Advanced age and poor performance status adversely influenced the achievement of complete remission, while neither aberrant β-catenin expression nor enhanced topo IIα activity did. On multivariate survival analysis, four factors independently predicted a shortened overall survival: aberrant β-catenin expression, high topo IIα activity, poor-risk cytogenetics, and presence of at least one comorbidity factor. Our results suggest that both β-catenin and topo IIα independently predicted an adverse prognosis and might serve as new markers for risk stratification in AML patients. Am. J. Hematol.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalAmerican Journal of Hematology
Volume84
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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