Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome

Chin Der Chen, Ming Yih Wu, Hsin Fu Chen, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: To determine the prognostic value of various cytokine levels in ascites and pleural effusion during the evolution of severe ovarian hyperstimulation syndrome (OHSS). Design: A longitudinal study. Setting: University teaching hospital. Patient(s): Twenty patients with severe OHSS who required either paracentesis or thoracentesis or both from whom ascites (n = 56) or pleural effusion (n = 12) samples were obtained. Control peritoneal fluid was obtained from 20 patients undergoing ovarian stimulation for IVF. Intervention(s): Abdominal paracentesis for tense ascites and thoracentesis for massive pleural effusion. Control peritoneal fluid was obtained before oocyte retrieval. Main Outcome Measure(s): Levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), E2, and progesterone concentrations in ascites and pleural effusion. Result(s): Levels of VEGF and IL-6 in ascites dropped significantly during the course of OHSS and were not correlated with E2 concentrations. Levels of VEGF were significantly correlated with levels of IL-1β, IL-8, and TNF-α, as well as progesterone concentrations, hematocrit, and white blood cell counts. None of the cytokine levels measured in pleural effusion were correlated with the course of OHSS. Conclusion(s): These results suggest that local cytokines might be involved in the evolution of severe OHSS and possibly serve as prognostic markers for this syndrome.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalFertility and Sterility
Volume72
Issue number2
DOIs
Publication statusPublished - Aug 1 1999
Externally publishedYes

Fingerprint

Vascular Endothelial Growth Factors
Endothelial Growth Factors
Ovarian Hyperstimulation Syndrome
Paracentesis
Artificial Insemination
Lymphokines
Pleural Effusion
Fertilization in Vitro
Interleukin-8
Interleukin-1
Punctures
Ascites
Vascular Endothelial Growth Factor A
Drainage
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Ascitic Fluid
Interleukin-1beta
Progesterone

Keywords

  • Ascites
  • Cytokines
  • Ovarian hyperstimulation syndrome
  • Pleural effusion

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome. / Chen, Chin Der; Wu, Ming Yih; Chen, Hsin Fu; Chen, Shee Uan; Ho, Hong Nerng; Yang, Yu Shih.

In: Fertility and Sterility, Vol. 72, No. 2, 01.08.1999, p. 286-292.

Research output: Contribution to journalArticle

Chen, Chin Der ; Wu, Ming Yih ; Chen, Hsin Fu ; Chen, Shee Uan ; Ho, Hong Nerng ; Yang, Yu Shih. / Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome. In: Fertility and Sterility. 1999 ; Vol. 72, No. 2. pp. 286-292.
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