Prognostic implications of myoclonic jerk in children with enterovirus infection

Hsiao Kuo Lu, Tzou Yien Lin, Shao Hsuan Hsia, Cheng Hsun Chiu, Yhu Chering Huang, Kuo Chien Tsao, Luan Yin Chang

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

To determine the prognostic value of myoclonic jerk in children with enterovirus 71 (EV71) infection, a retrospective study was conducted on 665 enterovirus culture-confirmed patients admitted to Chang Gung Children's Hospital from January 2000 to September 2001. The mean age was 35.0 months ± 32.2 months, ranging from 1 day to 15 years and 416 (62.6%) of them were male. Among these patients, 140 (21.1%) had EV71 isolated, and 150 (22.6%) had myoclonic jerk. Fifty one percent (72/140) of EV71 cases and only 15% (78/525) of non-EV71 cases had myoclonic jerk (p<0.001). The age of enterovirus patients with myoclonic jerk was younger than that of patients without myoclonic jerk (23.2 ± 17.6 vs 38.4 ± 34.6 months, p=0.005). The hospitalization and fever durations were significantly longer in the EV71 group than in the non-EV71 group (8.3 ± 13 vs 4.2 ± 2.7 days, p<0.001; 5.9 ± 4.8 vs 4.2 ± 3.0 days, p=0.009, respectively). Patients with myoclonic jerk also had higher percentages of severe illness, and neurologic sequelae (20% and 9%, respectively) than those without myoclonic jerk (5% and 1%, respectively) [p<0.001]. The positive predictive values of myoclonic jerk for EV71 infection, severe cases, and neurologic sequelae were 0.48, 0.20, and 0.09, respectively; the negative predictive values for severe cases and neurologic sequelae were 0.95 and 0.99, respectively. This study demonstrated that myoclonic jerk and EV71 infection are both independently associated with more severe disease and higher incidence of neurologic sequelae.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume37
Issue number2
Publication statusPublished - Apr 2004
Externally publishedYes

Fingerprint

Enterovirus Infections
Myoclonus
Enterovirus
Nervous System
Hospitalization
Fever
Retrospective Studies

Keywords

  • Enterovirus
  • Myoclonic jerk
  • Prognosis
  • Risk factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lu, H. K., Lin, T. Y., Hsia, S. H., Chiu, C. H., Huang, Y. C., Tsao, K. C., & Chang, L. Y. (2004). Prognostic implications of myoclonic jerk in children with enterovirus infection. Journal of Microbiology, Immunology and Infection, 37(2), 82-87.

Prognostic implications of myoclonic jerk in children with enterovirus infection. / Lu, Hsiao Kuo; Lin, Tzou Yien; Hsia, Shao Hsuan; Chiu, Cheng Hsun; Huang, Yhu Chering; Tsao, Kuo Chien; Chang, Luan Yin.

In: Journal of Microbiology, Immunology and Infection, Vol. 37, No. 2, 04.2004, p. 82-87.

Research output: Contribution to journalReview article

Lu, HK, Lin, TY, Hsia, SH, Chiu, CH, Huang, YC, Tsao, KC & Chang, LY 2004, 'Prognostic implications of myoclonic jerk in children with enterovirus infection', Journal of Microbiology, Immunology and Infection, vol. 37, no. 2, pp. 82-87.
Lu, Hsiao Kuo ; Lin, Tzou Yien ; Hsia, Shao Hsuan ; Chiu, Cheng Hsun ; Huang, Yhu Chering ; Tsao, Kuo Chien ; Chang, Luan Yin. / Prognostic implications of myoclonic jerk in children with enterovirus infection. In: Journal of Microbiology, Immunology and Infection. 2004 ; Vol. 37, No. 2. pp. 82-87.
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abstract = "To determine the prognostic value of myoclonic jerk in children with enterovirus 71 (EV71) infection, a retrospective study was conducted on 665 enterovirus culture-confirmed patients admitted to Chang Gung Children's Hospital from January 2000 to September 2001. The mean age was 35.0 months ± 32.2 months, ranging from 1 day to 15 years and 416 (62.6{\%}) of them were male. Among these patients, 140 (21.1{\%}) had EV71 isolated, and 150 (22.6{\%}) had myoclonic jerk. Fifty one percent (72/140) of EV71 cases and only 15{\%} (78/525) of non-EV71 cases had myoclonic jerk (p<0.001). The age of enterovirus patients with myoclonic jerk was younger than that of patients without myoclonic jerk (23.2 ± 17.6 vs 38.4 ± 34.6 months, p=0.005). The hospitalization and fever durations were significantly longer in the EV71 group than in the non-EV71 group (8.3 ± 13 vs 4.2 ± 2.7 days, p<0.001; 5.9 ± 4.8 vs 4.2 ± 3.0 days, p=0.009, respectively). Patients with myoclonic jerk also had higher percentages of severe illness, and neurologic sequelae (20{\%} and 9{\%}, respectively) than those without myoclonic jerk (5{\%} and 1{\%}, respectively) [p<0.001]. The positive predictive values of myoclonic jerk for EV71 infection, severe cases, and neurologic sequelae were 0.48, 0.20, and 0.09, respectively; the negative predictive values for severe cases and neurologic sequelae were 0.95 and 0.99, respectively. This study demonstrated that myoclonic jerk and EV71 infection are both independently associated with more severe disease and higher incidence of neurologic sequelae.",
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N2 - To determine the prognostic value of myoclonic jerk in children with enterovirus 71 (EV71) infection, a retrospective study was conducted on 665 enterovirus culture-confirmed patients admitted to Chang Gung Children's Hospital from January 2000 to September 2001. The mean age was 35.0 months ± 32.2 months, ranging from 1 day to 15 years and 416 (62.6%) of them were male. Among these patients, 140 (21.1%) had EV71 isolated, and 150 (22.6%) had myoclonic jerk. Fifty one percent (72/140) of EV71 cases and only 15% (78/525) of non-EV71 cases had myoclonic jerk (p<0.001). The age of enterovirus patients with myoclonic jerk was younger than that of patients without myoclonic jerk (23.2 ± 17.6 vs 38.4 ± 34.6 months, p=0.005). The hospitalization and fever durations were significantly longer in the EV71 group than in the non-EV71 group (8.3 ± 13 vs 4.2 ± 2.7 days, p<0.001; 5.9 ± 4.8 vs 4.2 ± 3.0 days, p=0.009, respectively). Patients with myoclonic jerk also had higher percentages of severe illness, and neurologic sequelae (20% and 9%, respectively) than those without myoclonic jerk (5% and 1%, respectively) [p<0.001]. The positive predictive values of myoclonic jerk for EV71 infection, severe cases, and neurologic sequelae were 0.48, 0.20, and 0.09, respectively; the negative predictive values for severe cases and neurologic sequelae were 0.95 and 0.99, respectively. This study demonstrated that myoclonic jerk and EV71 infection are both independently associated with more severe disease and higher incidence of neurologic sequelae.

AB - To determine the prognostic value of myoclonic jerk in children with enterovirus 71 (EV71) infection, a retrospective study was conducted on 665 enterovirus culture-confirmed patients admitted to Chang Gung Children's Hospital from January 2000 to September 2001. The mean age was 35.0 months ± 32.2 months, ranging from 1 day to 15 years and 416 (62.6%) of them were male. Among these patients, 140 (21.1%) had EV71 isolated, and 150 (22.6%) had myoclonic jerk. Fifty one percent (72/140) of EV71 cases and only 15% (78/525) of non-EV71 cases had myoclonic jerk (p<0.001). The age of enterovirus patients with myoclonic jerk was younger than that of patients without myoclonic jerk (23.2 ± 17.6 vs 38.4 ± 34.6 months, p=0.005). The hospitalization and fever durations were significantly longer in the EV71 group than in the non-EV71 group (8.3 ± 13 vs 4.2 ± 2.7 days, p<0.001; 5.9 ± 4.8 vs 4.2 ± 3.0 days, p=0.009, respectively). Patients with myoclonic jerk also had higher percentages of severe illness, and neurologic sequelae (20% and 9%, respectively) than those without myoclonic jerk (5% and 1%, respectively) [p<0.001]. The positive predictive values of myoclonic jerk for EV71 infection, severe cases, and neurologic sequelae were 0.48, 0.20, and 0.09, respectively; the negative predictive values for severe cases and neurologic sequelae were 0.95 and 0.99, respectively. This study demonstrated that myoclonic jerk and EV71 infection are both independently associated with more severe disease and higher incidence of neurologic sequelae.

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