Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin's lymphoma: The single-institute experience in Taiwan

Yu Hui Hu, Liang Tsai Hsiao, Ching Fen Yang, Tzeon Jye Chiou, Jin Hwang Liu, Jyh Pyng Gau, Chueh Chuan Yen, Teh Ying Chou, Wen Hu Hsu, Po Min Chen, Cheng Hwai Tzeng

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16 Citations (Scopus)

Abstract

Primary pulmonary lymphoma (PPL) accounts for less than 1% of patients with non-Hodgkin's lymphoma, with no report in Chinese patients. This study aims to analyze the clinical features and prognosis of this population. Patients with biopsy-proven pulmonary lymphoma were reviewed and re-classified by a hema-pathologist. Between 1992 and 2005, a total of 22 patients were identified (16 men and six women), with a mean age of 70 years. The histological subtypes included marginal zone B-cell lymphoma of mucosa-associated lymphoid tissues (MALT) in 12 patients (54%), diffuse large B-cell lymphoma in nine (41%), and one case of lymphomatoid granulomatosis. Diseases mainly manifested as pulmonary nodules or masses in 73% of patients, with a higher rate of hilar/ mediastinal lymphadenopathy in non-MALT patients (8% vs. 80%, P = 0.002). In eight patients (36% of 22), diagnoses were only conclusive until the biopsy via thoracotomy. Eighteen patients (82%) received chemotherapy. The 5-year rates of overall survival (OS) were 91% and 21% for MALT and non-MALT types of PPL, respectively. Patients who had received surgical resection tended to have a better 5-year OS rate (P = 0.077). The Cox-regression analysis showed that two factors - elevated serum lactate dehydrogenase level and hilar/mediastinal lymphadenopathy at diagnosis - were independently associated with a poor OS, with a hazard ratio of 10.370 and 5.171 (P = 0.01 and 0.033), respectively. In conclusion, the histological subtypes of Chinese PPL patients were similar to those in previous reports, with no increasing incidence of T-cell immunophenotype. The two prognostic factors provided additional information in managing these patients.

Original languageEnglish
Pages (from-to)839-846
Number of pages8
JournalAnnals of Hematology
Volume88
Issue number9
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • Lymphomatoid granulomatosis
  • Marginal zone B-cell lymphoma
  • Mucosa associated lymphoid tissue (MALT)
  • Primary pulmonary non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

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