Prognostic factors for pyogenic abscess of the liver

F. F. Chou, S. M. Sheen-Chen, Y. S. Chen, M. C. Chen, F. C. Chen, D. I. Tai

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Percutaneous drainage and antibiotics for pyogenic abscess are well established therapeutic modalities. However, the mortality rate for hepatic abscess of liver remains high. STUDY DESIGN: Three hundred fifty-two cases of pyogenic hepatic abscesses were studied to evaluate prognostic factors. RESULTS: Using univariate analysis, the following factors were associated with a high mortality rate: patient age, gas-forming abscess, rupture of abscess, bilobe involvement, clinical sepsis, bilirubin (more than 2 mg per dL), blood urea nitrogen (more than 20 mg per dL), serum creatinine (more than 2 mg per dL), aspartate aminotransferase (more than 100 U per L), and albumin (less than 2.5 gm per dL). Using multivariate analysis, the following were independent significant factors in predicting mortality: patient age (more than 60 years), blood urea nitrogen (greater than 20 mg per dL), serum creatinine (greater than 2 mg per dL), total bilirubin (greater than 2 mg per dL), and albumin (less than 2.5 gm per dL). CONCLUSIONS: Systemic effects of hepatic abscess with sepsis and multiple organ failure were significant factors in predicting mortality. Local findings, such as rupture of the abscesses, multiple abscesses, and gas-forming abscesses, were not independent factors. Percutaneous drainage is always considered if the condition of the patient can not be improved with antibiotic therapy. Operative treatment is indicated if the patient is unresponsive to medical treatment and percutaneous drainage or if the patient has complications of biliary tract stone or rupture of the abscess.

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalJournal of the American College of Surgeons
Volume179
Issue number6
Publication statusPublished - Jan 1 1994
Externally publishedYes

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Pyogenic Liver Abscess
Abscess
Rupture
Drainage
Liver Abscess
Mortality
Blood Urea Nitrogen
Bilirubin
Albumins
Creatinine
Sepsis
Gases
Anti-Bacterial Agents
Multiple Organ Failure
Biliary Tract
Therapeutics
Aspartate Aminotransferases
Serum
Statistical Factor Analysis
Multivariate Analysis

ASJC Scopus subject areas

  • Surgery

Cite this

Chou, F. F., Sheen-Chen, S. M., Chen, Y. S., Chen, M. C., Chen, F. C., & Tai, D. I. (1994). Prognostic factors for pyogenic abscess of the liver. Journal of the American College of Surgeons, 179(6), 727-732.

Prognostic factors for pyogenic abscess of the liver. / Chou, F. F.; Sheen-Chen, S. M.; Chen, Y. S.; Chen, M. C.; Chen, F. C.; Tai, D. I.

In: Journal of the American College of Surgeons, Vol. 179, No. 6, 01.01.1994, p. 727-732.

Research output: Contribution to journalArticle

Chou, FF, Sheen-Chen, SM, Chen, YS, Chen, MC, Chen, FC & Tai, DI 1994, 'Prognostic factors for pyogenic abscess of the liver', Journal of the American College of Surgeons, vol. 179, no. 6, pp. 727-732.
Chou FF, Sheen-Chen SM, Chen YS, Chen MC, Chen FC, Tai DI. Prognostic factors for pyogenic abscess of the liver. Journal of the American College of Surgeons. 1994 Jan 1;179(6):727-732.
Chou, F. F. ; Sheen-Chen, S. M. ; Chen, Y. S. ; Chen, M. C. ; Chen, F. C. ; Tai, D. I. / Prognostic factors for pyogenic abscess of the liver. In: Journal of the American College of Surgeons. 1994 ; Vol. 179, No. 6. pp. 727-732.
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