Prognostic and predictive values of Nrf2, Keap1, p16 and E-cadherin expression in ovarian epithelial carcinoma

Phui Ly Liew, Chun-Sen Hsu, Wei Min Liu, Yu Chieh Lee, Yi Chih Lee, Chi Long Chen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: Despite considerable interest in the Nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1), p16 and epithelial cadherin (E-cadherin) activation in carcinoma progression, contradictory results regarding association of Nrf2/Keap1/E-cadherin and p16 expression with clinico-pathological features and prognosis have been reported. The predictive value of these markers in ovarian carcinoma is unknown. Methods/Materials: In this retrospective study, 108 cases were evaluated immunohistochemically with antibodies to Nrf2, Keap1, estrogen receptor (ER), p16 and E-cadherin. The results were compared with histological and clinical data, disease-free survival (DFS) and overall survival (OS). Results: A cohort of 108 ovarian carcinomas (47 serous, 23 mucinous, 13 endometrioid and 25 clear cell), including 68 FIGO stage I-II cases and 40 FIGO stage III-IV cases was studied. The age of patients (P=0.005), FIGO stage (P

Original languageEnglish
Pages (from-to)5642-5649
Number of pages8
JournalInternational Journal of Clinical and Experimental Pathology
Volume8
Issue number5
Publication statusPublished - 2015

Keywords

  • E-Cadherin
  • Keap1
  • Nrf2
  • Ovarian cancer
  • P16

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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