Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22)

Chih Cheng Chen, Jyh Pyng Gau, An Bin Yu, Chang Hsien Lu, Kuan Der Lee, Jie Yu You

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients with AML with t(8;21)(q22;q22) were studied. Various parameters were tested for their impact on disease-free survival (DFS) and overall survival (OS). Another 55 patients with AML with a normal karyotype were included for comparison of clinical outcomes. Between patients with t(8;21) and those with a normal karyotype, no significant differences were noted in DFS (median survival, 15.23 vs 12.03 mo; P=.7626) and OS (median survival, 19.17 vs 18.93 mo; P=.7543). Among t(8;21)(q22;q22) patients, no clinical parameters showed a significant impact on DFS. Univariate analysis revealed that a higher platelet count (>15·10 9/L) at diagnosis, a low white blood cell count (index ≤20), and hematopoietic stem cell transplantation (HSCT) as postremission therapy were associated with improved OS. On multivariate analysis, HSCT as postremission therapy and white blood cell count index <20 remained good independent prognostic factors for OS. The data presented here suggest that t(8;21)(q22;q22) cytogenetic changes in patients with AML had prognostic significance similar to that in patients with a normal karyotype; patients who harbored either karyotype had parallel clinical outcomes. It is concluded that patients with AML with t(8;21)(q22;q22) would be compromised by treatment approaches that do not include HSCT as postremission therapy.

Original languageEnglish
Pages (from-to)907-920
Number of pages14
JournalAdvances in Therapy
Volume24
Issue number4
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Hematopoietic stem cell transplantation
  • Prognosis
  • t(8;21)

ASJC Scopus subject areas

  • Medicine(all)

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