Neomycin inhibits the production of interferon-β (IFN-β) in human fibroblast cells in response to Sendai virus or to poly(rI) · poly(rC) in a concentration-dependent manner, and to the greatest extent effective when added prior to or up to 2 h after induction. This inhibitory effect is negated when the protein kinase C activator, SC-9, is present during IFN-β production in response to poly(rI) · poly(rC), but not in response to Sendai virus. These results suggest that in human cells both virus and poly(rI) · poly(rC) utilize an early neomycin-sensitive signal transduction step for the production of IFN-β; because neomycin binds specific phosphatidylinositol phosphates, both of these inducers very likely require hydrolysis of these phosphates.
|Number of pages||5|
|Journal||Journal of Interferon Research|
|Publication status||Published - 1991|
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