Abstract

Typical electrospun polylactic acid (PLA) membranes revealing potential hydrophobicity and inflammation from acid release during degradation are major drawbacks as an ideal guided tissue regeneration (GTR) barrier. This study investigated the in vitro degradation properties of electrospun PLA/beta-tricalcium phosphate (β-TCP) membranes treated by polyethylene oxide dip-coating process. After surface modification, the membranes revealed good wettability in contact angle measurement. The addition of β-TCP can render good pH buffering properties for electrospun PLA membranes during the in vitro degradation test. The mechanical properties of the hybrid membrane showed no significant difference in suture pullout force at a dried or wetted state. For cell adhesion and proliferation, the membranes with hydrophilicity can enhance the cell attachment at early stage. Overall, these results show that electrospinning combined with dip coating is a feasible processing technology for producing hydrophilic fibrous GTR membranes.

Original languageEnglish
Pages (from-to)833-842
Number of pages10
JournalPolymer Engineering and Science
Volume53
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Phosphates
Membranes
Acids
Processing
Tissue regeneration
Degradation
Coatings
Cell adhesion
Hydrophilicity
Cell proliferation
Electrospinning
Hydrophobicity
Angle measurement
Polyethylene oxides
poly(lactic acid)
beta-tricalcium phosphate
Contact angle
Wetting
Surface treatment
Mechanical properties

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Chemistry(all)

Cite this

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title = "Processing and properties of hydrophilic electrospun polylactic acid/beta-tricalcium phosphate membrane for dental applications",
abstract = "Typical electrospun polylactic acid (PLA) membranes revealing potential hydrophobicity and inflammation from acid release during degradation are major drawbacks as an ideal guided tissue regeneration (GTR) barrier. This study investigated the in vitro degradation properties of electrospun PLA/beta-tricalcium phosphate (β-TCP) membranes treated by polyethylene oxide dip-coating process. After surface modification, the membranes revealed good wettability in contact angle measurement. The addition of β-TCP can render good pH buffering properties for electrospun PLA membranes during the in vitro degradation test. The mechanical properties of the hybrid membrane showed no significant difference in suture pullout force at a dried or wetted state. For cell adhesion and proliferation, the membranes with hydrophilicity can enhance the cell attachment at early stage. Overall, these results show that electrospinning combined with dip coating is a feasible processing technology for producing hydrophilic fibrous GTR membranes.",
author = "Hu, {Hsin Tai} and Lee, {Sheng Yang} and Chen, {Chien Chung} and Yang, {Yen Cheng} and Yang, {Jen Chang}",
year = "2013",
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AU - Hu, Hsin Tai

AU - Lee, Sheng Yang

AU - Chen, Chien Chung

AU - Yang, Yen Cheng

AU - Yang, Jen Chang

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N2 - Typical electrospun polylactic acid (PLA) membranes revealing potential hydrophobicity and inflammation from acid release during degradation are major drawbacks as an ideal guided tissue regeneration (GTR) barrier. This study investigated the in vitro degradation properties of electrospun PLA/beta-tricalcium phosphate (β-TCP) membranes treated by polyethylene oxide dip-coating process. After surface modification, the membranes revealed good wettability in contact angle measurement. The addition of β-TCP can render good pH buffering properties for electrospun PLA membranes during the in vitro degradation test. The mechanical properties of the hybrid membrane showed no significant difference in suture pullout force at a dried or wetted state. For cell adhesion and proliferation, the membranes with hydrophilicity can enhance the cell attachment at early stage. Overall, these results show that electrospinning combined with dip coating is a feasible processing technology for producing hydrophilic fibrous GTR membranes.

AB - Typical electrospun polylactic acid (PLA) membranes revealing potential hydrophobicity and inflammation from acid release during degradation are major drawbacks as an ideal guided tissue regeneration (GTR) barrier. This study investigated the in vitro degradation properties of electrospun PLA/beta-tricalcium phosphate (β-TCP) membranes treated by polyethylene oxide dip-coating process. After surface modification, the membranes revealed good wettability in contact angle measurement. The addition of β-TCP can render good pH buffering properties for electrospun PLA membranes during the in vitro degradation test. The mechanical properties of the hybrid membrane showed no significant difference in suture pullout force at a dried or wetted state. For cell adhesion and proliferation, the membranes with hydrophilicity can enhance the cell attachment at early stage. Overall, these results show that electrospinning combined with dip coating is a feasible processing technology for producing hydrophilic fibrous GTR membranes.

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