Probing the biological obstacles of nanomedicine with gold nanoparticles

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Despite massive growth in nanomedicine research to date, the field still lacks fundamental understanding of how certain physical and chemical features of a nanoparticle affect its ability to overcome biological obstacles in vivo and reach its intended target. To gain fundamental understanding of how physical and chemical parameters affect the biological outcomes of administered nanoparticles, model systems that can systematically manipulate a single parameter with minimal influence on others are needed. Gold nanoparticles are particularly good model systems in this case as one can synthetically control the physical dimensions and surface chemistry of the particles independently and with great precision. Additionally, the chemical and physical properties of gold allow particles to be detected and quantified in tissues and cells with high sensitivity. Through systematic biological studies using gold nanoparticles, insights toward rationally designed nanomedicine for in vivo imaging and therapy can be obtained. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Original languageEnglish
Article numbere1542
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume11
Issue number3
DOIs
Publication statusPublished - May 1 2019
Externally publishedYes

Keywords

  • active targeting
  • cancer imaging
  • drug delivery
  • oncology
  • passive targeting

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

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