Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.

Bo Rong Peng; Kuei Hung Lai; You Ying Chen; Jui Hsin Su; Yusheng M. Huang; Yu Hsin Chen; Mei Chin Lu; Steve Sheng Fa Yu; Chang Yih Duh; Ping Jyun Sung

doi:10.3390/md18020076

Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.

Bo Rong Peng, Kuei Hung Lai, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Yu Hsin Chen, Mei Chin Lu, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

Original language	English
Article number	76
Journal	Marine Drugs
Volume	18
Issue number	2
DOIs	https://doi.org/10.3390/md18020076
Publication status	Published - Jan 24 2020
Externally published	Yes

Keywords

Anti-proliferation
Lendenfeldia
Scalarane
Sesterterpenoid

ASJC Scopus subject areas

Drug Discovery

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10.3390/md18020076

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@article{2802a4a0a5bb4782927e7233bf5b038b,

title = "Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.",

abstract = "In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.",

keywords = "Anti-proliferation, Lendenfeldia, Scalarane, Sesterterpenoid",

author = "Peng, {Bo Rong} and Lai, {Kuei Hung} and Chen, {You Ying} and Su, {Jui Hsin} and Huang, {Yusheng M.} and Chen, {Yu Hsin} and Lu, {Mei Chin} and Yu, {Steve Sheng Fa} and Duh, {Chang Yih} and Sung, {Ping Jyun}",

year = "2020",

month = jan,

day = "24",

doi = "10.3390/md18020076",

language = "English",

volume = "18",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.

AU - Peng, Bo Rong

AU - Lai, Kuei Hung

AU - Chen, You Ying

AU - Su, Jui Hsin

AU - Huang, Yusheng M.

AU - Chen, Yu Hsin

AU - Lu, Mei Chin

AU - Yu, Steve Sheng Fa

AU - Duh, Chang Yih

AU - Sung, Ping Jyun

PY - 2020/1/24

Y1 - 2020/1/24

N2 - In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

AB - In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

KW - Anti-proliferation

KW - Lendenfeldia

KW - Scalarane

KW - Sesterterpenoid

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