Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.

Bo Rong Peng, Kuei Hung Lai, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Yu Hsin Chen, Mei Chin Lu, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

Original languageEnglish
Article number76
JournalMarine Drugs
Issue number2
Publication statusPublished - Jan 24 2020
Externally publishedYes


  • Anti-proliferation
  • Lendenfeldia
  • Scalarane
  • Sesterterpenoid

ASJC Scopus subject areas

  • Drug Discovery


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