Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum: A Taiwanese Gynecologic Oncology Group study

Chien Hsing Lu, I. Hui Chen, Yi Jen Chen, Kung Liahng Wang, Jian Tai Timothy Qiu, Hao Lin, Wu Chou Lin, Wen Shiung Liou, Yu Fang Huang, Yue Shan Lin, Yi Torng Tee, Yao Ching Hung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: This study aimed to determine the clinical prognostic factors involved in carcinosarcoma of the ovary, fallopian tube, and peritoneum. Materials and Methods: This retrospective study was undertaken by the Taiwanese Gynecologic Oncology Group. The retrieved clinical data included demographic characteristics, medical disease, tumor status, extent of surgery, and adjuvant chemotherapy. Results: In total, 63 patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum were identified. Sixty-one patients with complete datawere enrolled for further data analysis. The mean follow-up period was 1.0 year, and the mean overall survival was 15.4 months. By log-rank tests, age, menopausal status, parity, hypertension, diabetes, primary tumor size, para-aortic lymph node metastasis, pretreatment CA-125, preceding diagnostic surgery, hysterectomy, lymphadenectomy, other surgeries, and paclitaxel use were not predictive of overall survival. Omentectomy, no gross residual implants after surgery, platinum treatment, and no pelvic lymph node metastasis had a trend toward better survival. Early diagnosis at stage I and cisplatin/ifosfamide regimen were significant associated with a better overall survival in logrank and simple Cox regression tests. Bilateral ovarian tumors and metastatic tumors larger than 2 cm were significantly associated with a poorer overall survival. Conclusions: Early diagnosis at stage I, unilateral ovarian tumor, metastatic tumors less than 2 cm, and cisplatin/ifosfamide regimen were predictive of a better survival. Omentectomy and complete debulking surgery also showed a trend toward better survival. Thus, these treatment strategies should be applied in patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum. Ifosfamide, Paclitaxel, Debulking operation

Original languageEnglish
Pages (from-to)506-512
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Carcinosarcoma
Fallopian Tubes
Peritoneum
Ovary
Survival
Ifosfamide
Neoplasms
Paclitaxel
Cisplatin
Therapeutics
Early Diagnosis
Lymph Nodes
Neoplasm Metastasis
Adjuvant Chemotherapy
Parity
Platinum
Lymph Node Excision
Hysterectomy
Retrospective Studies
Demography

Keywords

  • Carcinosarcoma
  • Malignant mixed Müllerian tumor
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

Cite this

Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum : A Taiwanese Gynecologic Oncology Group study. / Lu, Chien Hsing; Chen, I. Hui; Chen, Yi Jen; Wang, Kung Liahng; Qiu, Jian Tai Timothy; Lin, Hao; Lin, Wu Chou; Liou, Wen Shiung; Huang, Yu Fang; Lin, Yue Shan; Tee, Yi Torng; Hung, Yao Ching.

In: International Journal of Gynecological Cancer, Vol. 24, No. 3, 2014, p. 506-512.

Research output: Contribution to journalArticle

Lu, Chien Hsing ; Chen, I. Hui ; Chen, Yi Jen ; Wang, Kung Liahng ; Qiu, Jian Tai Timothy ; Lin, Hao ; Lin, Wu Chou ; Liou, Wen Shiung ; Huang, Yu Fang ; Lin, Yue Shan ; Tee, Yi Torng ; Hung, Yao Ching. / Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum : A Taiwanese Gynecologic Oncology Group study. In: International Journal of Gynecological Cancer. 2014 ; Vol. 24, No. 3. pp. 506-512.
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abstract = "Objective: This study aimed to determine the clinical prognostic factors involved in carcinosarcoma of the ovary, fallopian tube, and peritoneum. Materials and Methods: This retrospective study was undertaken by the Taiwanese Gynecologic Oncology Group. The retrieved clinical data included demographic characteristics, medical disease, tumor status, extent of surgery, and adjuvant chemotherapy. Results: In total, 63 patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum were identified. Sixty-one patients with complete datawere enrolled for further data analysis. The mean follow-up period was 1.0 year, and the mean overall survival was 15.4 months. By log-rank tests, age, menopausal status, parity, hypertension, diabetes, primary tumor size, para-aortic lymph node metastasis, pretreatment CA-125, preceding diagnostic surgery, hysterectomy, lymphadenectomy, other surgeries, and paclitaxel use were not predictive of overall survival. Omentectomy, no gross residual implants after surgery, platinum treatment, and no pelvic lymph node metastasis had a trend toward better survival. Early diagnosis at stage I and cisplatin/ifosfamide regimen were significant associated with a better overall survival in logrank and simple Cox regression tests. Bilateral ovarian tumors and metastatic tumors larger than 2 cm were significantly associated with a poorer overall survival. Conclusions: Early diagnosis at stage I, unilateral ovarian tumor, metastatic tumors less than 2 cm, and cisplatin/ifosfamide regimen were predictive of a better survival. Omentectomy and complete debulking surgery also showed a trend toward better survival. Thus, these treatment strategies should be applied in patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum. Ifosfamide, Paclitaxel, Debulking operation",
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T1 - Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum

T2 - A Taiwanese Gynecologic Oncology Group study

AU - Lu, Chien Hsing

AU - Chen, I. Hui

AU - Chen, Yi Jen

AU - Wang, Kung Liahng

AU - Qiu, Jian Tai Timothy

AU - Lin, Hao

AU - Lin, Wu Chou

AU - Liou, Wen Shiung

AU - Huang, Yu Fang

AU - Lin, Yue Shan

AU - Tee, Yi Torng

AU - Hung, Yao Ching

PY - 2014

Y1 - 2014

N2 - Objective: This study aimed to determine the clinical prognostic factors involved in carcinosarcoma of the ovary, fallopian tube, and peritoneum. Materials and Methods: This retrospective study was undertaken by the Taiwanese Gynecologic Oncology Group. The retrieved clinical data included demographic characteristics, medical disease, tumor status, extent of surgery, and adjuvant chemotherapy. Results: In total, 63 patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum were identified. Sixty-one patients with complete datawere enrolled for further data analysis. The mean follow-up period was 1.0 year, and the mean overall survival was 15.4 months. By log-rank tests, age, menopausal status, parity, hypertension, diabetes, primary tumor size, para-aortic lymph node metastasis, pretreatment CA-125, preceding diagnostic surgery, hysterectomy, lymphadenectomy, other surgeries, and paclitaxel use were not predictive of overall survival. Omentectomy, no gross residual implants after surgery, platinum treatment, and no pelvic lymph node metastasis had a trend toward better survival. Early diagnosis at stage I and cisplatin/ifosfamide regimen were significant associated with a better overall survival in logrank and simple Cox regression tests. Bilateral ovarian tumors and metastatic tumors larger than 2 cm were significantly associated with a poorer overall survival. Conclusions: Early diagnosis at stage I, unilateral ovarian tumor, metastatic tumors less than 2 cm, and cisplatin/ifosfamide regimen were predictive of a better survival. Omentectomy and complete debulking surgery also showed a trend toward better survival. Thus, these treatment strategies should be applied in patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum. Ifosfamide, Paclitaxel, Debulking operation

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KW - Carcinosarcoma

KW - Malignant mixed Müllerian tumor

KW - Ovarian cancer

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