Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study

Tze Chien Chen, Huei Jean Huang, Tao Yeuan Wang, Lan Yan Yang, Chi Hau Chen, Ya Min Cheng, Wen Hsiung Liou, Shih Tien Hsu, Kuo Chang Wen, Yu Che Ou, Yao Ching Hung, Hung Cheng Lai, Chih Ming Ho, Ting Chang Chang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5 cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.

Original languageEnglish
Pages (from-to)468-473
Number of pages6
JournalGynecologic Oncology
Volume137
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Small Cell Carcinoma
Cervix Uteri
Radiotherapy
Drug Therapy
Adjuvant Chemotherapy
Survival
Recurrence
Platinum
Taiwan
Medical Records
Neoplasms
Retrospective Studies

Keywords

  • Cervical cancer
  • Platinum-based chemotherapy
  • Radiation therapy
  • Radical hysterectomy
  • Small cell carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

Cite this

Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix : A retrospective Taiwanese Gynecologic Oncology Group study. / Chen, Tze Chien; Huang, Huei Jean; Wang, Tao Yeuan; Yang, Lan Yan; Chen, Chi Hau; Cheng, Ya Min; Liou, Wen Hsiung; Hsu, Shih Tien; Wen, Kuo Chang; Ou, Yu Che; Hung, Yao Ching; Lai, Hung Cheng; Ho, Chih Ming; Chang, Ting Chang.

In: Gynecologic Oncology, Vol. 137, No. 3, 01.06.2015, p. 468-473.

Research output: Contribution to journalArticle

Chen, TC, Huang, HJ, Wang, TY, Yang, LY, Chen, CH, Cheng, YM, Liou, WH, Hsu, ST, Wen, KC, Ou, YC, Hung, YC, Lai, HC, Ho, CM & Chang, TC 2015, 'Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study', Gynecologic Oncology, vol. 137, no. 3, pp. 468-473. https://doi.org/10.1016/j.ygyno.2015.03.015
Chen, Tze Chien ; Huang, Huei Jean ; Wang, Tao Yeuan ; Yang, Lan Yan ; Chen, Chi Hau ; Cheng, Ya Min ; Liou, Wen Hsiung ; Hsu, Shih Tien ; Wen, Kuo Chang ; Ou, Yu Che ; Hung, Yao Ching ; Lai, Hung Cheng ; Ho, Chih Ming ; Chang, Ting Chang. / Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix : A retrospective Taiwanese Gynecologic Oncology Group study. In: Gynecologic Oncology. 2015 ; Vol. 137, No. 3. pp. 468-473.
@article{f9842f8861134d5a83b7ebe1129ad777,
title = "Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study",
abstract = "Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6{\%} vs. 27{\%}; P = 0.009). The 5-year overall survival (OS) was 89{\%} for 13 surgically treated patients with cervical tumor {\^a}‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5 cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78{\%}, better than that of 46{\%} by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.",
keywords = "Cervical cancer, Platinum-based chemotherapy, Radiation therapy, Radical hysterectomy, Small cell carcinoma",
author = "Chen, {Tze Chien} and Huang, {Huei Jean} and Wang, {Tao Yeuan} and Yang, {Lan Yan} and Chen, {Chi Hau} and Cheng, {Ya Min} and Liou, {Wen Hsiung} and Hsu, {Shih Tien} and Wen, {Kuo Chang} and Ou, {Yu Che} and Hung, {Yao Ching} and Lai, {Hung Cheng} and Ho, {Chih Ming} and Chang, {Ting Chang}",
year = "2015",
month = "6",
day = "1",
doi = "10.1016/j.ygyno.2015.03.015",
language = "English",
volume = "137",
pages = "468--473",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix

T2 - A retrospective Taiwanese Gynecologic Oncology Group study

AU - Chen, Tze Chien

AU - Huang, Huei Jean

AU - Wang, Tao Yeuan

AU - Yang, Lan Yan

AU - Chen, Chi Hau

AU - Cheng, Ya Min

AU - Liou, Wen Hsiung

AU - Hsu, Shih Tien

AU - Wen, Kuo Chang

AU - Ou, Yu Che

AU - Hung, Yao Ching

AU - Lai, Hung Cheng

AU - Ho, Chih Ming

AU - Chang, Ting Chang

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5 cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.

AB - Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5 cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.

KW - Cervical cancer

KW - Platinum-based chemotherapy

KW - Radiation therapy

KW - Radical hysterectomy

KW - Small cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84930046571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930046571&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2015.03.015

DO - 10.1016/j.ygyno.2015.03.015

M3 - Article

C2 - 25797082

AN - SCOPUS:84930046571

VL - 137

SP - 468

EP - 473

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -