Primary Sjögren's syndrome and the risk of acute myocardial infarction: A nationwide study

Chia Hung Chiang, Chia Jen Liu, Ping Jen Chen, Hsin Bang Leu, Chien Yi Hsu, Po Hsun Huang, Tzeng Ji Chen, Shing Jong Lin, Jaw Wen Chen, Wan Leong Chan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sjögren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. Methods: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. Results: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95% confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. Conclusions: PSS is not associated with a higher risk of subsequent AMI.

Original languageEnglish
Pages (from-to)124-131
Number of pages8
JournalActa Cardiologica Sinica
Volume29
Issue number2
Publication statusPublished - Mar 1 2013
Externally publishedYes

Fingerprint

Myocardial Infarction
Autoimmune Diseases
Catastrophic Illness
National Health Programs
Hyperlipidemias
Taiwan
Chronic Renal Insufficiency
Registries
Coronary Artery Disease
Cohort Studies
Multivariate Analysis
Databases
Confidence Intervals
Hypertension
Control Groups
Incidence
Research

Keywords

  • Acute myocardial infarction
  • Atherosclerosis
  • Primary Sjögren's syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chiang, C. H., Liu, C. J., Chen, P. J., Leu, H. B., Hsu, C. Y., Huang, P. H., ... Chan, W. L. (2013). Primary Sjögren's syndrome and the risk of acute myocardial infarction: A nationwide study. Acta Cardiologica Sinica, 29(2), 124-131.

Primary Sjögren's syndrome and the risk of acute myocardial infarction : A nationwide study. / Chiang, Chia Hung; Liu, Chia Jen; Chen, Ping Jen; Leu, Hsin Bang; Hsu, Chien Yi; Huang, Po Hsun; Chen, Tzeng Ji; Lin, Shing Jong; Chen, Jaw Wen; Chan, Wan Leong.

In: Acta Cardiologica Sinica, Vol. 29, No. 2, 01.03.2013, p. 124-131.

Research output: Contribution to journalArticle

Chiang, CH, Liu, CJ, Chen, PJ, Leu, HB, Hsu, CY, Huang, PH, Chen, TJ, Lin, SJ, Chen, JW & Chan, WL 2013, 'Primary Sjögren's syndrome and the risk of acute myocardial infarction: A nationwide study', Acta Cardiologica Sinica, vol. 29, no. 2, pp. 124-131.
Chiang, Chia Hung ; Liu, Chia Jen ; Chen, Ping Jen ; Leu, Hsin Bang ; Hsu, Chien Yi ; Huang, Po Hsun ; Chen, Tzeng Ji ; Lin, Shing Jong ; Chen, Jaw Wen ; Chan, Wan Leong. / Primary Sjögren's syndrome and the risk of acute myocardial infarction : A nationwide study. In: Acta Cardiologica Sinica. 2013 ; Vol. 29, No. 2. pp. 124-131.
@article{86f250e0d6a6413c84cf0536e2fba446,
title = "Primary Sj{\"o}gren's syndrome and the risk of acute myocardial infarction: A nationwide study",
abstract = "Background: Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sj{\"o}gren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. Methods: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. Results: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95{\%} confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. Conclusions: PSS is not associated with a higher risk of subsequent AMI.",
keywords = "Acute myocardial infarction, Atherosclerosis, Primary Sj{\"o}gren's syndrome",
author = "Chiang, {Chia Hung} and Liu, {Chia Jen} and Chen, {Ping Jen} and Leu, {Hsin Bang} and Hsu, {Chien Yi} and Huang, {Po Hsun} and Chen, {Tzeng Ji} and Lin, {Shing Jong} and Chen, {Jaw Wen} and Chan, {Wan Leong}",
year = "2013",
month = "3",
day = "1",
language = "English",
volume = "29",
pages = "124--131",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
publisher = "Republic of China Society of Cardiology",
number = "2",

}

TY - JOUR

T1 - Primary Sjögren's syndrome and the risk of acute myocardial infarction

T2 - A nationwide study

AU - Chiang, Chia Hung

AU - Liu, Chia Jen

AU - Chen, Ping Jen

AU - Leu, Hsin Bang

AU - Hsu, Chien Yi

AU - Huang, Po Hsun

AU - Chen, Tzeng Ji

AU - Lin, Shing Jong

AU - Chen, Jaw Wen

AU - Chan, Wan Leong

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Background: Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sjögren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. Methods: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. Results: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95% confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. Conclusions: PSS is not associated with a higher risk of subsequent AMI.

AB - Background: Patients with autoimmune diseases have a high cardiovascular risk. However, few data are available on the risk of acute myocardial infarction (AMI) in patients diagnosed with primary Sjögren's syndrome (PSS). We conducted a large nationwide cohort study to investigate the possible association between PSS and the risk of AMI. Methods: Between the years 2000-2006, a total of 5205 patients with newly diagnosed PSS and no history of AMI were identified from the Registry of Catastrophic Illness, a sub-dataset of the National Health Insurance Research Database in Taiwan. The control group, which consisted of subjects without systemic autoimmune disease or previous AMI, was matched by the date of enrollment, age, gender, history of coronary artery disease, diabetes, hypertension, chronic kidney disease, and hyperlipidemia. The study endpoints were the occurrence of AMI. Results: Of the 5205 subjects with PSS and 5205 controls included in the study, 77 (35 PSS patients and 42 controls) developed AMI during the mean 3.7-year (interquartile range, 2.1-5.1 years) follow-up period. The incidence of AMI was similar in PSS patients and controls (1.91/1000 versus 2.25/1000 person-years). Multivariate analysis adjusted for baseline covariates demonstrated an insignificant association between PSS and AMI [adjusted hazard ratio, 0.86; 95% confidence interval (CI), 0.55-1.35; p = 0.506], suggesting that PSS does not increase the risk of AMI. Conclusions: PSS is not associated with a higher risk of subsequent AMI.

KW - Acute myocardial infarction

KW - Atherosclerosis

KW - Primary Sjögren's syndrome

UR - http://www.scopus.com/inward/record.url?scp=84878333512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878333512&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84878333512

VL - 29

SP - 124

EP - 131

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

SN - 1011-6842

IS - 2

ER -