Primary Sjögren's syndrome and risk of ischemic stroke: A nationwide study

Chia Hung Chiang, Chia Jen Liu, Ping Jen Chen, Chin Chou Huang, Chien Yi Hsu, Wan Leong Chan, Po Hsun Huang, Tzeng Ji Chen, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Few studies are available on the risk of ischemic stroke after a diagnosis of primary Sjögren's syndrome (PSS). This study investigated whether PSS increased the risk of ischemic stroke in a large, nationwide cohort. Data for 4,276 patients who were newly diagnosed with PSS from 2000 to 2006 and who did not have a stroke prior to diagnosis of PSS were obtained from the Registry of Catastrophic Illness in Taiwan. For each PSS patient, data for ten controls (matched by age, gender, comorbidities, and enrollment date) without systemic autoimmune disease or previous stroke were obtained from the Longitudinal Health Insurance 2000 database. All study subjects were followed up from the date of enrollment until they developed ischemic stroke, died, or until the end of 2006, whichever was earliest. To investigate if PSS was an independent factor in determining the risk of developing ischemic stroke, a Cox regression model was used with adjustment for age, gender, and comorbid disorders. Among 4,276 PSS patients and 42,760 controls, 669 subjects (51 PSS patients and 618 controls) developed ischemic stroke during the mean 3.7-year follow-up period (interquartile range 2.2-5.2 years). Patients with PSS and controls had a similar incidence of ischemic stroke occurrence (3.17/1,000 vs. 3.90/1,000 person years). Multivariate analysis adjusted for baseline covariates indicated that PSS did not increase the risk of ischemic stroke (adjusted hazard ratio: 0.84, 95 % confidence interval: 0.63-1.12, P=0.244). PSS is not associated with an increased risk of ischemic stroke subsequent to diagnosis.

Original languageEnglish
Pages (from-to)931-937
Number of pages7
JournalClinical Rheumatology
Volume33
Issue number7
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Stroke
Catastrophic Illness
Health Insurance
Taiwan
Proportional Hazards Models
Autoimmune Diseases
Registries
Comorbidity
Multivariate Analysis
Databases
Confidence Intervals
Incidence

Keywords

  • Atherosclerosis
  • Ischemic stroke
  • Primary Sjögren's syndrome

ASJC Scopus subject areas

  • Rheumatology

Cite this

Chiang, C. H., Liu, C. J., Chen, P. J., Huang, C. C., Hsu, C. Y., Chan, W. L., ... Leu, H. B. (2014). Primary Sjögren's syndrome and risk of ischemic stroke: A nationwide study. Clinical Rheumatology, 33(7), 931-937. https://doi.org/10.1007/s10067-014-2573-7

Primary Sjögren's syndrome and risk of ischemic stroke : A nationwide study. / Chiang, Chia Hung; Liu, Chia Jen; Chen, Ping Jen; Huang, Chin Chou; Hsu, Chien Yi; Chan, Wan Leong; Huang, Po Hsun; Chen, Tzeng Ji; Lin, Shing Jong; Chen, Jaw Wen; Leu, Hsin Bang.

In: Clinical Rheumatology, Vol. 33, No. 7, 01.01.2014, p. 931-937.

Research output: Contribution to journalArticle

Chiang, CH, Liu, CJ, Chen, PJ, Huang, CC, Hsu, CY, Chan, WL, Huang, PH, Chen, TJ, Lin, SJ, Chen, JW & Leu, HB 2014, 'Primary Sjögren's syndrome and risk of ischemic stroke: A nationwide study', Clinical Rheumatology, vol. 33, no. 7, pp. 931-937. https://doi.org/10.1007/s10067-014-2573-7
Chiang, Chia Hung ; Liu, Chia Jen ; Chen, Ping Jen ; Huang, Chin Chou ; Hsu, Chien Yi ; Chan, Wan Leong ; Huang, Po Hsun ; Chen, Tzeng Ji ; Lin, Shing Jong ; Chen, Jaw Wen ; Leu, Hsin Bang. / Primary Sjögren's syndrome and risk of ischemic stroke : A nationwide study. In: Clinical Rheumatology. 2014 ; Vol. 33, No. 7. pp. 931-937.
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AU - Chen, Ping Jen

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AU - Hsu, Chien Yi

AU - Chan, Wan Leong

AU - Huang, Po Hsun

AU - Chen, Tzeng Ji

AU - Lin, Shing Jong

AU - Chen, Jaw Wen

AU - Leu, Hsin Bang

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N2 - Few studies are available on the risk of ischemic stroke after a diagnosis of primary Sjögren's syndrome (PSS). This study investigated whether PSS increased the risk of ischemic stroke in a large, nationwide cohort. Data for 4,276 patients who were newly diagnosed with PSS from 2000 to 2006 and who did not have a stroke prior to diagnosis of PSS were obtained from the Registry of Catastrophic Illness in Taiwan. For each PSS patient, data for ten controls (matched by age, gender, comorbidities, and enrollment date) without systemic autoimmune disease or previous stroke were obtained from the Longitudinal Health Insurance 2000 database. All study subjects were followed up from the date of enrollment until they developed ischemic stroke, died, or until the end of 2006, whichever was earliest. To investigate if PSS was an independent factor in determining the risk of developing ischemic stroke, a Cox regression model was used with adjustment for age, gender, and comorbid disorders. Among 4,276 PSS patients and 42,760 controls, 669 subjects (51 PSS patients and 618 controls) developed ischemic stroke during the mean 3.7-year follow-up period (interquartile range 2.2-5.2 years). Patients with PSS and controls had a similar incidence of ischemic stroke occurrence (3.17/1,000 vs. 3.90/1,000 person years). Multivariate analysis adjusted for baseline covariates indicated that PSS did not increase the risk of ischemic stroke (adjusted hazard ratio: 0.84, 95 % confidence interval: 0.63-1.12, P=0.244). PSS is not associated with an increased risk of ischemic stroke subsequent to diagnosis.

AB - Few studies are available on the risk of ischemic stroke after a diagnosis of primary Sjögren's syndrome (PSS). This study investigated whether PSS increased the risk of ischemic stroke in a large, nationwide cohort. Data for 4,276 patients who were newly diagnosed with PSS from 2000 to 2006 and who did not have a stroke prior to diagnosis of PSS were obtained from the Registry of Catastrophic Illness in Taiwan. For each PSS patient, data for ten controls (matched by age, gender, comorbidities, and enrollment date) without systemic autoimmune disease or previous stroke were obtained from the Longitudinal Health Insurance 2000 database. All study subjects were followed up from the date of enrollment until they developed ischemic stroke, died, or until the end of 2006, whichever was earliest. To investigate if PSS was an independent factor in determining the risk of developing ischemic stroke, a Cox regression model was used with adjustment for age, gender, and comorbid disorders. Among 4,276 PSS patients and 42,760 controls, 669 subjects (51 PSS patients and 618 controls) developed ischemic stroke during the mean 3.7-year follow-up period (interquartile range 2.2-5.2 years). Patients with PSS and controls had a similar incidence of ischemic stroke occurrence (3.17/1,000 vs. 3.90/1,000 person years). Multivariate analysis adjusted for baseline covariates indicated that PSS did not increase the risk of ischemic stroke (adjusted hazard ratio: 0.84, 95 % confidence interval: 0.63-1.12, P=0.244). PSS is not associated with an increased risk of ischemic stroke subsequent to diagnosis.

KW - Atherosclerosis

KW - Ischemic stroke

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