Primary pediatric brain tumors

Statistics of Taipei VGH, Taiwan (1975-2004)

Tai-Tong Wong, Donald M. Ho, Kai Ping Chang, Sang Hue Yen, Wan You Guo, Feng Chi Chang, Muh Lii Liang, Hung Chi Pan, Wen Yuh Chung

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

BACKGROUND. The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan. METHODS. The authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004. Age and gender distribution, location, and classification of brain tumors were analyzed. Intracranial tumors with diagnostic imaging were included. Nontumoral lesions, cysts, and vascular malformations were excluded. RESULTS. The mean age of these 986 patients was 7.8 years, and the male to female ratio was 1.4:1. Supratentorial (including pineal-quadrigeminal) located tumors (58.3%) was predominant to infratentorial tumors (41.1%). In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients). The most common 5 categories of tumors were astrocytic tumors (31.1%), germ cell tumors (14.0%), medulloblastomas (13.3%), craniopharyngiomas (8.3%), and ependymal tumors (5.8%). Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1%. The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea. For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem. CONCLUSIONS. The authors analyzed a large hospital series of primary brain tumors in children. Both histologically verified and unverified tumors were recruited to avoid selective bias. Although it was not a study of a population-based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan.

Original languageEnglish
Pages (from-to)2156-2167
Number of pages12
JournalCancer
Volume104
Issue number10
DOIs
Publication statusPublished - Nov 15 2005
Externally publishedYes

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Veterans Hospitals
Taiwan
Brain Neoplasms
General Hospitals
Pediatrics
Neoplasms
Germ Cell and Embryonal Neoplasms
Infratentorial Neoplasms
Brain Stem Neoplasms
Craniopharyngioma
Vascular Malformations
Medulloblastoma
Age Distribution
Diagnostic Imaging
Korea
Registries
Cysts
Japan
Databases
Incidence

Keywords

  • Brain tumor
  • Childhood
  • Demographic data
  • Taiwan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wong, T-T., Ho, D. M., Chang, K. P., Yen, S. H., Guo, W. Y., Chang, F. C., ... Chung, W. Y. (2005). Primary pediatric brain tumors: Statistics of Taipei VGH, Taiwan (1975-2004). Cancer, 104(10), 2156-2167. https://doi.org/10.1002/cncr.21430

Primary pediatric brain tumors : Statistics of Taipei VGH, Taiwan (1975-2004). / Wong, Tai-Tong; Ho, Donald M.; Chang, Kai Ping; Yen, Sang Hue; Guo, Wan You; Chang, Feng Chi; Liang, Muh Lii; Pan, Hung Chi; Chung, Wen Yuh.

In: Cancer, Vol. 104, No. 10, 15.11.2005, p. 2156-2167.

Research output: Contribution to journalReview article

Wong, T-T, Ho, DM, Chang, KP, Yen, SH, Guo, WY, Chang, FC, Liang, ML, Pan, HC & Chung, WY 2005, 'Primary pediatric brain tumors: Statistics of Taipei VGH, Taiwan (1975-2004)', Cancer, vol. 104, no. 10, pp. 2156-2167. https://doi.org/10.1002/cncr.21430
Wong T-T, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC et al. Primary pediatric brain tumors: Statistics of Taipei VGH, Taiwan (1975-2004). Cancer. 2005 Nov 15;104(10):2156-2167. https://doi.org/10.1002/cncr.21430
Wong, Tai-Tong ; Ho, Donald M. ; Chang, Kai Ping ; Yen, Sang Hue ; Guo, Wan You ; Chang, Feng Chi ; Liang, Muh Lii ; Pan, Hung Chi ; Chung, Wen Yuh. / Primary pediatric brain tumors : Statistics of Taipei VGH, Taiwan (1975-2004). In: Cancer. 2005 ; Vol. 104, No. 10. pp. 2156-2167.
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abstract = "BACKGROUND. The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan. METHODS. The authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004. Age and gender distribution, location, and classification of brain tumors were analyzed. Intracranial tumors with diagnostic imaging were included. Nontumoral lesions, cysts, and vascular malformations were excluded. RESULTS. The mean age of these 986 patients was 7.8 years, and the male to female ratio was 1.4:1. Supratentorial (including pineal-quadrigeminal) located tumors (58.3{\%}) was predominant to infratentorial tumors (41.1{\%}). In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients). The most common 5 categories of tumors were astrocytic tumors (31.1{\%}), germ cell tumors (14.0{\%}), medulloblastomas (13.3{\%}), craniopharyngiomas (8.3{\%}), and ependymal tumors (5.8{\%}). Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1{\%}. The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea. For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem. CONCLUSIONS. The authors analyzed a large hospital series of primary brain tumors in children. Both histologically verified and unverified tumors were recruited to avoid selective bias. Although it was not a study of a population-based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan.",
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AU - Wong, Tai-Tong

AU - Ho, Donald M.

AU - Chang, Kai Ping

AU - Yen, Sang Hue

AU - Guo, Wan You

AU - Chang, Feng Chi

AU - Liang, Muh Lii

AU - Pan, Hung Chi

AU - Chung, Wen Yuh

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N2 - BACKGROUND. The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan. METHODS. The authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004. Age and gender distribution, location, and classification of brain tumors were analyzed. Intracranial tumors with diagnostic imaging were included. Nontumoral lesions, cysts, and vascular malformations were excluded. RESULTS. The mean age of these 986 patients was 7.8 years, and the male to female ratio was 1.4:1. Supratentorial (including pineal-quadrigeminal) located tumors (58.3%) was predominant to infratentorial tumors (41.1%). In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients). The most common 5 categories of tumors were astrocytic tumors (31.1%), germ cell tumors (14.0%), medulloblastomas (13.3%), craniopharyngiomas (8.3%), and ependymal tumors (5.8%). Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1%. The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea. For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem. CONCLUSIONS. The authors analyzed a large hospital series of primary brain tumors in children. Both histologically verified and unverified tumors were recruited to avoid selective bias. Although it was not a study of a population-based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan.

AB - BACKGROUND. The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan. METHODS. The authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004. Age and gender distribution, location, and classification of brain tumors were analyzed. Intracranial tumors with diagnostic imaging were included. Nontumoral lesions, cysts, and vascular malformations were excluded. RESULTS. The mean age of these 986 patients was 7.8 years, and the male to female ratio was 1.4:1. Supratentorial (including pineal-quadrigeminal) located tumors (58.3%) was predominant to infratentorial tumors (41.1%). In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients). The most common 5 categories of tumors were astrocytic tumors (31.1%), germ cell tumors (14.0%), medulloblastomas (13.3%), craniopharyngiomas (8.3%), and ependymal tumors (5.8%). Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1%. The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea. For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem. CONCLUSIONS. The authors analyzed a large hospital series of primary brain tumors in children. Both histologically verified and unverified tumors were recruited to avoid selective bias. Although it was not a study of a population-based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan.

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KW - Childhood

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