Primary neuroendocrine carcinoma of the breast

Chieh Sheng Lu, Shing Hwa Huang, Chiang Liang Ho, Jia Hong Chen, Tsu Yi Chao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Primary neuroendocrine carcinoma of the breast (NECB) is a rare distinct type of breast carcinoma. There are only some case reports on this topic published in the past. There is still little known on the optimal treatment outcomes, while a wide variety of treatments is proposed by several authors. In this study we searched the literature on NECB in PubMed to clarify its prognosis and possible optimal therapeutic strategies. Methods: Eighty-six cases of primary NEC, included our case, were collected from PubMed between 1980 and 2013. Initial stage, estrogen receptor (ER/progesterone receptor (PR)/ human epidermal growth factor receptor 2 (HER-2), surgical procedures, adjuvant treatment and overall survive (OS) were analyzed using the Statistical Package for the Social Sciences (SPSS, v 16.0). Results: All 86 patients enrolled were eligible. Their mean age at diagnosis was 53.9 years (range 25-83) and 1 case was in a male. Overall survival (OS) at 48 months was 83.5%. Patients with enlarged tumor size (10 patients with tumor size >5.0 cm) or advanced stage (stage III 15 patients, stage IV 2 patients) had poor OS (48-month OS: 51.4 vs 97.1% with tumors >5cm vs

Original languageEnglish
Pages (from-to)419-429
Number of pages11
JournalJournal of B.U.ON.
Volume19
Issue number2
Publication statusPublished - 2014

Keywords

  • Breast
  • Estrogen receptor
  • Hormone therapy
  • Neuroendocrine carcinoma
  • Progesterone receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Lu, C. S., Huang, S. H., Ho, C. L., Chen, J. H., & Chao, T. Y. (2014). Primary neuroendocrine carcinoma of the breast. Journal of B.U.ON., 19(2), 419-429.