Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule

Dan Xue, Xiuzhen Li, Yunqing Ren, Qi Liu, Yun Yen, Lijun Xue

Research output: Contribution to journalArticle

4 Citations (Scopus)


Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a distinct entity from systemic ALCL (sALCL). sALCL usually shows immunohistochemical positivity for anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA), whereas these tests are negative in pcALCL. In contrast to sALCL, pcALCL is rarely found in children and young adults. We present here a case of a rare clinical condition in a 21-year-old woman, who has pcALCL with positive ALK and patchy EMA expression. She experiences a large, rapidly growing nodule without any outside-nodule manifestation. In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL.

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalInternational Journal of Surgical Pathology
Issue number4
Publication statusPublished - Jun 3 2015
Externally publishedYes



  • Anaplastic lymphoma kinase
  • Epithelial membrane antigen
  • Primary cutaneous anaplastic large cell lymphoma
  • Systemic anaplastic large cell lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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