Abstract
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a distinct entity from systemic ALCL (sALCL). sALCL usually shows immunohistochemical positivity for anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA), whereas these tests are negative in pcALCL. In contrast to sALCL, pcALCL is rarely found in children and young adults. We present here a case of a rare clinical condition in a 21-year-old woman, who has pcALCL with positive ALK and patchy EMA expression. She experiences a large, rapidly growing nodule without any outside-nodule manifestation. In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL.
| Original language | English |
|---|---|
| Pages (from-to) | 333-335 |
| Number of pages | 3 |
| Journal | International Journal of Surgical Pathology |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jun 3 2015 |
| Externally published | Yes |
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Keywords
- Anaplastic lymphoma kinase
- Epithelial membrane antigen
- Primary cutaneous anaplastic large cell lymphoma
- Systemic anaplastic large cell lymphoma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule. / Xue, Dan; Li, Xiuzhen; Ren, Yunqing; Liu, Qi; Yen, Yun; Xue, Lijun.
In: International Journal of Surgical Pathology, Vol. 23, No. 4, 03.06.2015, p. 333-335.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule
AU - Xue, Dan
AU - Li, Xiuzhen
AU - Ren, Yunqing
AU - Liu, Qi
AU - Yen, Yun
AU - Xue, Lijun
PY - 2015/6/3
Y1 - 2015/6/3
N2 - Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a distinct entity from systemic ALCL (sALCL). sALCL usually shows immunohistochemical positivity for anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA), whereas these tests are negative in pcALCL. In contrast to sALCL, pcALCL is rarely found in children and young adults. We present here a case of a rare clinical condition in a 21-year-old woman, who has pcALCL with positive ALK and patchy EMA expression. She experiences a large, rapidly growing nodule without any outside-nodule manifestation. In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL.
AB - Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a distinct entity from systemic ALCL (sALCL). sALCL usually shows immunohistochemical positivity for anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA), whereas these tests are negative in pcALCL. In contrast to sALCL, pcALCL is rarely found in children and young adults. We present here a case of a rare clinical condition in a 21-year-old woman, who has pcALCL with positive ALK and patchy EMA expression. She experiences a large, rapidly growing nodule without any outside-nodule manifestation. In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL.
KW - Anaplastic lymphoma kinase
KW - Epithelial membrane antigen
KW - Primary cutaneous anaplastic large cell lymphoma
KW - Systemic anaplastic large cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84930510482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930510482&partnerID=8YFLogxK
U2 - 10.1177/1066896915568993
DO - 10.1177/1066896915568993
M3 - Article
C2 - 25633507
AN - SCOPUS:84930510482
VL - 23
SP - 333
EP - 335
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 4
ER -