Preventive effects of rice bran oil on 1,2-dimethylhydrazine/dextran sodium sulphate-induced colon carcinogenesis in rats

Chun Kuang Shih, Chia Jung Ho, Sing Chung Li, Shwu Huey Yang, Wen Chi Hou, Hsing-Hsien Cheng

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study included F344 rats which were fed AIN-93G-based 14% high-fat diets and were divided into the following six groups: Groups B and N, 14% soybean oil (SO); group P, 14% SO containing 0.04% piroxicam; group L, 5% rice bran oil (RBO) and 9% SO; group M, 9% RBO and 5% SO; and group H, 14% RBO. All the rats - except those in group B - were administered 1,2-dimethylhydrazine/ dextran sodium sulphate to induce colitis-related colon carcinogenesis. The rats were sacrificed, and their colons were removed to examine aberrant crypt foci (ACF) and mucin-depleted foci (MDF). The results revealed that the rats from all the RBO group rats exhibited significantly reduced colon tumour formation, MDF, and ACF, especially sialomucin (SIM)-producing ACF. The hepatic antioxidant status, including the glutathione (GSH) and thiobarbituric acid reactive substance levels as well as superoxide dismutase and catalase activities, was superior among the RBO groups, which might contribute to the potential of RBO with respect to delaying colon carcinogenesis.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalFood Chemistry
Volume126
Issue number2
DOIs
Publication statusPublished - May 15 2011

Fingerprint

1,2-dimethylhydrazine
1,2-Dimethylhydrazine
rice bran oil
Dextran Sulfate
sodium sulfate
dextran
carcinogenesis
colon
Rats
Soybean Oil
Colon
Carcinogenesis
Aberrant Crypt Foci
soybean oil
rats
mucins
Mucins
Sialomucins
Piroxicam
Thiobarbituric Acid Reactive Substances

Keywords

  • Aberrant crypt foci (ACF)
  • Antioxidant
  • Colon cancer
  • Mucin-depleted foci (MDF)
  • Rice bran oil (RBO)

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

Preventive effects of rice bran oil on 1,2-dimethylhydrazine/dextran sodium sulphate-induced colon carcinogenesis in rats. / Shih, Chun Kuang; Ho, Chia Jung; Li, Sing Chung; Yang, Shwu Huey; Hou, Wen Chi; Cheng, Hsing-Hsien.

In: Food Chemistry, Vol. 126, No. 2, 15.05.2011, p. 562-567.

Research output: Contribution to journalArticle

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