Preventive effects of monascus on androgen-related diseases: Androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer

Hui Wen Chiu, Mei Huei Chen, Wen Hung Fang, Ching Ming Hung, Yen Lin Chen, Ming Der Wu, Gwo Fang Yuan, Ming Jiuan Wu, Ying Jan Wang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone- induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.

Original languageEnglish
Pages (from-to)4379-4386
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume61
Issue number18
DOIs
Publication statusPublished - May 8 2013
Externally publishedYes

Keywords

  • androgenetic alopecia
  • benign prostate hyperplasia
  • Monascus
  • prostate cancer

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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