Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate

Yung Tsung Chau, Hsin Yuan Chen, Po Han Lin, Shih Min Hsia

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Abstract

The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.

Original languageEnglish
Article number343
JournalMarine Drugs
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 10 2019

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Keywords

  • Fucoidan
  • Fucoxanthin
  • Hyperuricemia
  • Uric acid
  • Xanthine oxidase

ASJC Scopus subject areas

  • Drug Discovery

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