Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate

Yung Tsung Chau, Hsin Yuan Chen, Po Han Lin, Shih Min Hsia

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.

Original languageEnglish
Article number343
JournalMarine Drugs
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 10 2019

Fingerprint

Hyperuricemia
Xanthine Oxidase
Uric Acid
Hypoxanthine
Control Groups
Urine
Kidney
Liver
Sprague Dawley Rats
fucoidan
potassium oxonate
fucoxanthin
Serum
Proteins

Keywords

  • Fucoidan
  • Fucoxanthin
  • Hyperuricemia
  • Uric acid
  • Xanthine oxidase

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate. / Chau, Yung Tsung; Chen, Hsin Yuan; Lin, Po Han; Hsia, Shih Min.

In: Marine Drugs, Vol. 17, No. 6, 343, 10.06.2019.

Research output: Contribution to journalArticle

@article{a47f77ea9c604cf59ea074dadce5a80d,
title = "Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate",
abstract = "The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.",
keywords = "Fucoidan, Fucoxanthin, Hyperuricemia, Uric acid, Xanthine oxidase",
author = "Chau, {Yung Tsung} and Chen, {Hsin Yuan} and Lin, {Po Han} and Hsia, {Shih Min}",
year = "2019",
month = "6",
day = "10",
doi = "10.3390/md17060343",
language = "English",
volume = "17",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

TY - JOUR

T1 - Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate

AU - Chau, Yung Tsung

AU - Chen, Hsin Yuan

AU - Lin, Po Han

AU - Hsia, Shih Min

PY - 2019/6/10

Y1 - 2019/6/10

N2 - The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.

AB - The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.

KW - Fucoidan

KW - Fucoxanthin

KW - Hyperuricemia

KW - Uric acid

KW - Xanthine oxidase

UR - http://www.scopus.com/inward/record.url?scp=85067079095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067079095&partnerID=8YFLogxK

U2 - 10.3390/md17060343

DO - 10.3390/md17060343

M3 - Article

C2 - 31185695

AN - SCOPUS:85067079095

VL - 17

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

IS - 6

M1 - 343

ER -