2 Citations (Scopus)

Abstract

Multiple randomized trials indicated that antiplatelet agents, including aspirin alone, clopidogrel alone, and combined aspirin plus extended-release dipyridamole, can prevent recurrent stroke effectively. Previous findings indicated that aspirin plus extended-release dipyridamole is more effective than aspirin alone for the secondary prevention of stroke. Clopidogrel has been thought as effective as aspirin in the prevention of recurrent stroke. Thus, aspirin plus extended-release dipyridamole has been suggested to be superior to clopidogrel alone for preventing recurrent stroke based on indirect meta-analysis. However, the first clinical trial comparing aspirin plus extended-release dipyridamole and clopidogrel monotherapy directly revealed that aspirin plus extended-release dipyridamole is not different with clopidogrel alone in the risk of recurrent stroke significantly, which is not accordant to the early reports. Therefore, it is not known whether the more expensive agents like aspirin plus extended-release dipyridamole and clopidogrel could reduce the risk of recurrent stroke more effectively than aspirin alone. The 2011 American Heart Association/American Stroke Association guideline showed that aspirin alone, aspirin plus extended-release dipyridamole, and clopidogrel alone are acceptable choice for preventing recurrent stroke, but without a strong suggestion of preference. However, the 2012 update of the American College of Chest Physicians guideline indicated the superiority of aspirin plus dipyridamole for the secondary prevention of stroke compared with aspirin alone, but with a question about the truly beneficial effects on recurrent stroke with aspirin plus dipyridamole. A recent retrospective analysis of large patient numbers from Taiwan Stoke Registry (N = 10,792) indicated that aspirin regimen is not inferior to those more expensive agents such as aspirin plus dipyridamole or clopidogrel alone. In conclusion, based on the well-known efficacy and relative low cost, aspirin is effective as initial antiplatelet therapy for the secondary prevention of stroke in patients with ischemic stroke or transient ischemic attack.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

clopidogrel
Aspirin
Stroke
Dipyridamole
Secondary Prevention
Guidelines
Platelet Aggregation Inhibitors
Transient Ischemic Attack
Dipyridamole Drug Combination Aspirin
Taiwan

Keywords

  • Aspirin
  • Clopidogrel
  • Dipyridamole
  • Secondary stroke prevention

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Preventive Effectiveness of Aspirin on Recurrent Stroke. / Shiau, Ya Fang; Hu, Chaur Jong; Chiueh, Chuang Chin.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 4, No. 4, 08.2012, p. 203-208.

Research output: Contribution to journalArticle

@article{b02731e3e735458b918a4a11870fe429,
title = "Preventive Effectiveness of Aspirin on Recurrent Stroke",
abstract = "Multiple randomized trials indicated that antiplatelet agents, including aspirin alone, clopidogrel alone, and combined aspirin plus extended-release dipyridamole, can prevent recurrent stroke effectively. Previous findings indicated that aspirin plus extended-release dipyridamole is more effective than aspirin alone for the secondary prevention of stroke. Clopidogrel has been thought as effective as aspirin in the prevention of recurrent stroke. Thus, aspirin plus extended-release dipyridamole has been suggested to be superior to clopidogrel alone for preventing recurrent stroke based on indirect meta-analysis. However, the first clinical trial comparing aspirin plus extended-release dipyridamole and clopidogrel monotherapy directly revealed that aspirin plus extended-release dipyridamole is not different with clopidogrel alone in the risk of recurrent stroke significantly, which is not accordant to the early reports. Therefore, it is not known whether the more expensive agents like aspirin plus extended-release dipyridamole and clopidogrel could reduce the risk of recurrent stroke more effectively than aspirin alone. The 2011 American Heart Association/American Stroke Association guideline showed that aspirin alone, aspirin plus extended-release dipyridamole, and clopidogrel alone are acceptable choice for preventing recurrent stroke, but without a strong suggestion of preference. However, the 2012 update of the American College of Chest Physicians guideline indicated the superiority of aspirin plus dipyridamole for the secondary prevention of stroke compared with aspirin alone, but with a question about the truly beneficial effects on recurrent stroke with aspirin plus dipyridamole. A recent retrospective analysis of large patient numbers from Taiwan Stoke Registry (N = 10,792) indicated that aspirin regimen is not inferior to those more expensive agents such as aspirin plus dipyridamole or clopidogrel alone. In conclusion, based on the well-known efficacy and relative low cost, aspirin is effective as initial antiplatelet therapy for the secondary prevention of stroke in patients with ischemic stroke or transient ischemic attack.",
keywords = "Aspirin, Clopidogrel, Dipyridamole, Secondary stroke prevention",
author = "Shiau, {Ya Fang} and Hu, {Chaur Jong} and Chiueh, {Chuang Chin}",
year = "2012",
month = "8",
doi = "10.1016/j.jecm.2012.06.009",
language = "English",
volume = "4",
pages = "203--208",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "4",

}

TY - JOUR

T1 - Preventive Effectiveness of Aspirin on Recurrent Stroke

AU - Shiau, Ya Fang

AU - Hu, Chaur Jong

AU - Chiueh, Chuang Chin

PY - 2012/8

Y1 - 2012/8

N2 - Multiple randomized trials indicated that antiplatelet agents, including aspirin alone, clopidogrel alone, and combined aspirin plus extended-release dipyridamole, can prevent recurrent stroke effectively. Previous findings indicated that aspirin plus extended-release dipyridamole is more effective than aspirin alone for the secondary prevention of stroke. Clopidogrel has been thought as effective as aspirin in the prevention of recurrent stroke. Thus, aspirin plus extended-release dipyridamole has been suggested to be superior to clopidogrel alone for preventing recurrent stroke based on indirect meta-analysis. However, the first clinical trial comparing aspirin plus extended-release dipyridamole and clopidogrel monotherapy directly revealed that aspirin plus extended-release dipyridamole is not different with clopidogrel alone in the risk of recurrent stroke significantly, which is not accordant to the early reports. Therefore, it is not known whether the more expensive agents like aspirin plus extended-release dipyridamole and clopidogrel could reduce the risk of recurrent stroke more effectively than aspirin alone. The 2011 American Heart Association/American Stroke Association guideline showed that aspirin alone, aspirin plus extended-release dipyridamole, and clopidogrel alone are acceptable choice for preventing recurrent stroke, but without a strong suggestion of preference. However, the 2012 update of the American College of Chest Physicians guideline indicated the superiority of aspirin plus dipyridamole for the secondary prevention of stroke compared with aspirin alone, but with a question about the truly beneficial effects on recurrent stroke with aspirin plus dipyridamole. A recent retrospective analysis of large patient numbers from Taiwan Stoke Registry (N = 10,792) indicated that aspirin regimen is not inferior to those more expensive agents such as aspirin plus dipyridamole or clopidogrel alone. In conclusion, based on the well-known efficacy and relative low cost, aspirin is effective as initial antiplatelet therapy for the secondary prevention of stroke in patients with ischemic stroke or transient ischemic attack.

AB - Multiple randomized trials indicated that antiplatelet agents, including aspirin alone, clopidogrel alone, and combined aspirin plus extended-release dipyridamole, can prevent recurrent stroke effectively. Previous findings indicated that aspirin plus extended-release dipyridamole is more effective than aspirin alone for the secondary prevention of stroke. Clopidogrel has been thought as effective as aspirin in the prevention of recurrent stroke. Thus, aspirin plus extended-release dipyridamole has been suggested to be superior to clopidogrel alone for preventing recurrent stroke based on indirect meta-analysis. However, the first clinical trial comparing aspirin plus extended-release dipyridamole and clopidogrel monotherapy directly revealed that aspirin plus extended-release dipyridamole is not different with clopidogrel alone in the risk of recurrent stroke significantly, which is not accordant to the early reports. Therefore, it is not known whether the more expensive agents like aspirin plus extended-release dipyridamole and clopidogrel could reduce the risk of recurrent stroke more effectively than aspirin alone. The 2011 American Heart Association/American Stroke Association guideline showed that aspirin alone, aspirin plus extended-release dipyridamole, and clopidogrel alone are acceptable choice for preventing recurrent stroke, but without a strong suggestion of preference. However, the 2012 update of the American College of Chest Physicians guideline indicated the superiority of aspirin plus dipyridamole for the secondary prevention of stroke compared with aspirin alone, but with a question about the truly beneficial effects on recurrent stroke with aspirin plus dipyridamole. A recent retrospective analysis of large patient numbers from Taiwan Stoke Registry (N = 10,792) indicated that aspirin regimen is not inferior to those more expensive agents such as aspirin plus dipyridamole or clopidogrel alone. In conclusion, based on the well-known efficacy and relative low cost, aspirin is effective as initial antiplatelet therapy for the secondary prevention of stroke in patients with ischemic stroke or transient ischemic attack.

KW - Aspirin

KW - Clopidogrel

KW - Dipyridamole

KW - Secondary stroke prevention

UR - http://www.scopus.com/inward/record.url?scp=84865725319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865725319&partnerID=8YFLogxK

U2 - 10.1016/j.jecm.2012.06.009

DO - 10.1016/j.jecm.2012.06.009

M3 - Article

AN - SCOPUS:84865725319

VL - 4

SP - 203

EP - 208

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 4

ER -