Prevention of Chronic Lung Disease (CLD) in premature infants with RDS

Research output: Contribution to journalArticle

Abstract

Exogenous surfactant therapies significantly reduce mortality of the infants. However, the incidence of CLD is not clearly decreased by exogenous surfactant therapies, particulary in very low birth weight infants. The judicious use of diuretics and bronchodilators and the proper use of mechanical ventilation appeared to be beneficial in improving lung function and in decreasing oxygen requirement and barotrauma. However, these effects are often transient and appear to have no long term effect on CLD morbidity. Superoxide Dismutase and vitamin A may reduce CLD, but more studies are needed to confirm this conclusion. Dexamethasone given at two weeks or older does not affect CLD morbidity. The early use of Dexamethasone may decrease lung injuries and improve CLD morbidity. However, in order to avoid immediate side effects and possible long term adverse effect, a modified therapeutic regimen is needed.

Original languageEnglish
JournalJournal of the Singapore Paediatric Society
Volume36
Issue numberSUPPL. 1
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Premature Infants
Lung Diseases
Chronic Disease
Morbidity
Surface-Active Agents
Dexamethasone
Barotrauma
Very Low Birth Weight Infant
Bronchodilator Agents
Infant Mortality
Lung Injury
Vitamin A
Artificial Respiration
Diuretics
Superoxide Dismutase
Therapeutics
Oxygen
Lung
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Prevention of Chronic Lung Disease (CLD) in premature infants with RDS. / Yeh, T. F.

In: Journal of the Singapore Paediatric Society, Vol. 36, No. SUPPL. 1, 01.01.1994.

Research output: Contribution to journalArticle

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