Prevention of cellular ROS damage by isovitexin and related flavonoids

Chun-Mao Lin, Chien-Tsu Chen, Hsiao Hui Lee, Jen-Kun Lin

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC 50 value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC 50 values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC 50 value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD 50 >400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalPlanta Medica
Volume68
Issue number4
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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