Prevention of acute radiation-associated toxicity by traditional chinese medicine Tianwang Buxin Mini-pills in patients with head and neck cancer

Kao Shin Lin, Yee Min Jen, Tsu Yi Chao, Yaoh Shiang Lin, Li Hsiang Wang, Chien Jung Lin, Yi Chang Su, Shung Tai Ho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Anemia and oral mucositis are main side effects of radiotherapy (RT) and are important factors affecting the quality of life (QOL) in head and neck cancer (HNC) patients treated with RT. This study aimed to explore the safety and therapeutic efficacy of Tianwang Buxin Mini-pills (TWBXM) for the prevention of acute RT toxicity in HNC patients by using a randomized, double-blind and placebo-controlled study design. Patients and Methods: Seventy-three HNC patients participated the study. They were randomized into a treatment group (n = 38) and a control group (n = 35). All patients received daily either TWBXM treatment or placebo starting from the initiation of RT until 1-month follow-up after RT completion. All patients were evaluated for QOL, acute RT toxicities and laboratory data (hemoglobin [Hgb], white blood cell and platelet) at 3 time points: Pre-RT, upon RT completion and at TWBXM completion. Results: The TWBXM group maintained normal levels of Hgb during the duration of the study while the placebo group showed a decrease in Hgb (P = 0.035). Conclusions: This study demonstrated the safety and efficacy of TWBXM applied in the HNC patients receiving RT. It prevented the decrease of Hgb in HNC patients undergoing RT treatment as well 1-month-post-RT treatment. Further studies are needed to assess the effects of TWBXM for the prevention of other RT toxicities.

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalJournal of Medical Sciences (Taiwan)
Volume34
Issue number4
DOIs
Publication statusPublished - 2014

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Chinese Traditional Medicine
Head and Neck Neoplasms
Radiotherapy
Radiation
Hemoglobins
Placebos
Quality of Life
Therapeutics
Safety
Stomatitis
Anemia
Leukocytes
Blood Platelets

Keywords

  • Head and neck cancer
  • Radiotherapy
  • Tianwang Buxin Mini-pills
  • Toxicities
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevention of acute radiation-associated toxicity by traditional chinese medicine Tianwang Buxin Mini-pills in patients with head and neck cancer. / Lin, Kao Shin; Jen, Yee Min; Chao, Tsu Yi; Lin, Yaoh Shiang; Wang, Li Hsiang; Lin, Chien Jung; Su, Yi Chang; Ho, Shung Tai.

In: Journal of Medical Sciences (Taiwan), Vol. 34, No. 4, 2014, p. 152-160.

Research output: Contribution to journalArticle

Lin, Kao Shin ; Jen, Yee Min ; Chao, Tsu Yi ; Lin, Yaoh Shiang ; Wang, Li Hsiang ; Lin, Chien Jung ; Su, Yi Chang ; Ho, Shung Tai. / Prevention of acute radiation-associated toxicity by traditional chinese medicine Tianwang Buxin Mini-pills in patients with head and neck cancer. In: Journal of Medical Sciences (Taiwan). 2014 ; Vol. 34, No. 4. pp. 152-160.
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abstract = "Background: Anemia and oral mucositis are main side effects of radiotherapy (RT) and are important factors affecting the quality of life (QOL) in head and neck cancer (HNC) patients treated with RT. This study aimed to explore the safety and therapeutic efficacy of Tianwang Buxin Mini-pills (TWBXM) for the prevention of acute RT toxicity in HNC patients by using a randomized, double-blind and placebo-controlled study design. Patients and Methods: Seventy-three HNC patients participated the study. They were randomized into a treatment group (n = 38) and a control group (n = 35). All patients received daily either TWBXM treatment or placebo starting from the initiation of RT until 1-month follow-up after RT completion. All patients were evaluated for QOL, acute RT toxicities and laboratory data (hemoglobin [Hgb], white blood cell and platelet) at 3 time points: Pre-RT, upon RT completion and at TWBXM completion. Results: The TWBXM group maintained normal levels of Hgb during the duration of the study while the placebo group showed a decrease in Hgb (P = 0.035). Conclusions: This study demonstrated the safety and efficacy of TWBXM applied in the HNC patients receiving RT. It prevented the decrease of Hgb in HNC patients undergoing RT treatment as well 1-month-post-RT treatment. Further studies are needed to assess the effects of TWBXM for the prevention of other RT toxicities.",
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AU - Lin, Kao Shin

AU - Jen, Yee Min

AU - Chao, Tsu Yi

AU - Lin, Yaoh Shiang

AU - Wang, Li Hsiang

AU - Lin, Chien Jung

AU - Su, Yi Chang

AU - Ho, Shung Tai

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N2 - Background: Anemia and oral mucositis are main side effects of radiotherapy (RT) and are important factors affecting the quality of life (QOL) in head and neck cancer (HNC) patients treated with RT. This study aimed to explore the safety and therapeutic efficacy of Tianwang Buxin Mini-pills (TWBXM) for the prevention of acute RT toxicity in HNC patients by using a randomized, double-blind and placebo-controlled study design. Patients and Methods: Seventy-three HNC patients participated the study. They were randomized into a treatment group (n = 38) and a control group (n = 35). All patients received daily either TWBXM treatment or placebo starting from the initiation of RT until 1-month follow-up after RT completion. All patients were evaluated for QOL, acute RT toxicities and laboratory data (hemoglobin [Hgb], white blood cell and platelet) at 3 time points: Pre-RT, upon RT completion and at TWBXM completion. Results: The TWBXM group maintained normal levels of Hgb during the duration of the study while the placebo group showed a decrease in Hgb (P = 0.035). Conclusions: This study demonstrated the safety and efficacy of TWBXM applied in the HNC patients receiving RT. It prevented the decrease of Hgb in HNC patients undergoing RT treatment as well 1-month-post-RT treatment. Further studies are needed to assess the effects of TWBXM for the prevention of other RT toxicities.

AB - Background: Anemia and oral mucositis are main side effects of radiotherapy (RT) and are important factors affecting the quality of life (QOL) in head and neck cancer (HNC) patients treated with RT. This study aimed to explore the safety and therapeutic efficacy of Tianwang Buxin Mini-pills (TWBXM) for the prevention of acute RT toxicity in HNC patients by using a randomized, double-blind and placebo-controlled study design. Patients and Methods: Seventy-three HNC patients participated the study. They were randomized into a treatment group (n = 38) and a control group (n = 35). All patients received daily either TWBXM treatment or placebo starting from the initiation of RT until 1-month follow-up after RT completion. All patients were evaluated for QOL, acute RT toxicities and laboratory data (hemoglobin [Hgb], white blood cell and platelet) at 3 time points: Pre-RT, upon RT completion and at TWBXM completion. Results: The TWBXM group maintained normal levels of Hgb during the duration of the study while the placebo group showed a decrease in Hgb (P = 0.035). Conclusions: This study demonstrated the safety and efficacy of TWBXM applied in the HNC patients receiving RT. It prevented the decrease of Hgb in HNC patients undergoing RT treatment as well 1-month-post-RT treatment. Further studies are needed to assess the effects of TWBXM for the prevention of other RT toxicities.

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KW - Radiotherapy

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