Prevalence of von Willebrand disease in women with iron deficiency anaemia and menorrhagia in Taiwan

Yeu Chin Chen, T. Y. Chao, S. N. Cheng, S. H. Hu, J. Y. Liu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Iron deficiency anaemia (IDA) is a frequently encountered disease, which can be attributed to menorrhagia. Most female patients with von Willebrand disease (VWD) have menorrhagia. The aim of this study was to investigate the prevalence of VWD in women with both IDA and menorrhagia in Taiwan. From January to December 2005 and November 2006 to January 2007, 56 consecutive patients with both IDA and menorrhagia were enrolled in this study. Their median age was 41 years (range 18-53). IDA was diagnosed by anaemia plus either low ferritin or transferrin saturation. Menorrhagia was evaluated by patient's menses history. Both von Willebrand factor antigen (VWF:Ag) and ristocetin cofactor activity (VWF:RCo) were measured for each patient. Bleeding time (BT) and platelet function analyser (PFA)-100 assay were determined as ancillary tests. The VWD diagnosis was established if: (i) both VWF:Ag (

Original languageEnglish
Pages (from-to)768-774
Number of pages7
JournalHaemophilia
Volume14
Issue number4
DOIs
Publication statusPublished - Jul 2008
Externally publishedYes

Keywords

  • Iron deficiency anaemia
  • Menorrhagia
  • von Willebrand disease

ASJC Scopus subject areas

  • Hematology

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