Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome

a cross-sectional study of Chinese infertility patients

Hsiao Jui Wei, Robert Young, I. Li Kuo, Chian Mey Liaw, Han-Sun Chiang, Ching Ying Yeh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To determine the prevalence of abnormalities in glucose metabolism in patients with polycystic ovary syndrome (PCOS) and control infertility patients in Taiwan, and to determine the predictive risk factors for PCOS. Design: Cross-sectional study. Setting: Infertility Center, Taiwan Adventist Hospital. Patient(s): Three hundred fifty-six patients with PCOS and 974 control infertility patients. Intervention(s): None. Main Outcomes Measure(s): Hormone assay and 75-g oral glucose tolerance test. Result(s): Patients with PCOS were younger (32.7 vs. 35.3 years) with a higher body mass index (BMI) (22.4 vs. 20.6 kg/m2) than controls. Even after BMI adjustment, patients with PCOS still had significantly higher fasting glucose (97.2 vs. 94.4 mg/dL), fasting insulin (5.6 vs. 4.1 μIU/mL), 2-hour glucose (108.1 vs. 96.0 mg/dL), and 2-hour insulin levels (38.0 vs. 27.0 μIU/mL), and higher homeostasis model assessment of insulin resistance (HOMA-IR) values (1.3 vs. 1.0) than control patients. The prevalence of impaired glucose tolerance and diabetes mellitus in patients with PCOS was 7.6% and 3.1%, respectively, compared with 2.9% and 0.2% in the control group, respectively. Only fasting glucose and insulin, 2-hour insulin, HOMA-IR, age, androstenedione, and status (PCOS vs. control) had a significant impact on 2-hour glucose level. However, BMI and waist/hip ratio did not show a significant impact on 2-hour glucose level. Conclusion(s): Chinese women with PCOS are at increased risk for insulin resistance and glucose intolerance compared with controls. Body mass index failed to show significant impact on 2-hour glucose levels in our infertility patients.

Original languageEnglish
Pages (from-to)1864-1868
Number of pages5
JournalFertility and Sterility
Volume91
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Glucose Intolerance
Polycystic Ovary Syndrome
Infertility
Insulin Resistance
Cross-Sectional Studies
Glucose
Body Mass Index
Insulin
Fasting
Taiwan
Homeostasis
Social Adjustment
Waist-Hip Ratio
Androstenedione
Glucose Tolerance Test
Diabetes Mellitus
Outcome Assessment (Health Care)
Hormones
Control Groups

Keywords

  • Chinese infertility patients
  • glucose intolerance
  • insulin resistance
  • OGTT
  • risk factors

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome : a cross-sectional study of Chinese infertility patients. / Wei, Hsiao Jui; Young, Robert; Kuo, I. Li; Liaw, Chian Mey; Chiang, Han-Sun; Yeh, Ching Ying.

In: Fertility and Sterility, Vol. 91, No. 5, 05.2009, p. 1864-1868.

Research output: Contribution to journalArticle

Wei, Hsiao Jui ; Young, Robert ; Kuo, I. Li ; Liaw, Chian Mey ; Chiang, Han-Sun ; Yeh, Ching Ying. / Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome : a cross-sectional study of Chinese infertility patients. In: Fertility and Sterility. 2009 ; Vol. 91, No. 5. pp. 1864-1868.
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AB - Objective: To determine the prevalence of abnormalities in glucose metabolism in patients with polycystic ovary syndrome (PCOS) and control infertility patients in Taiwan, and to determine the predictive risk factors for PCOS. Design: Cross-sectional study. Setting: Infertility Center, Taiwan Adventist Hospital. Patient(s): Three hundred fifty-six patients with PCOS and 974 control infertility patients. Intervention(s): None. Main Outcomes Measure(s): Hormone assay and 75-g oral glucose tolerance test. Result(s): Patients with PCOS were younger (32.7 vs. 35.3 years) with a higher body mass index (BMI) (22.4 vs. 20.6 kg/m2) than controls. Even after BMI adjustment, patients with PCOS still had significantly higher fasting glucose (97.2 vs. 94.4 mg/dL), fasting insulin (5.6 vs. 4.1 μIU/mL), 2-hour glucose (108.1 vs. 96.0 mg/dL), and 2-hour insulin levels (38.0 vs. 27.0 μIU/mL), and higher homeostasis model assessment of insulin resistance (HOMA-IR) values (1.3 vs. 1.0) than control patients. The prevalence of impaired glucose tolerance and diabetes mellitus in patients with PCOS was 7.6% and 3.1%, respectively, compared with 2.9% and 0.2% in the control group, respectively. Only fasting glucose and insulin, 2-hour insulin, HOMA-IR, age, androstenedione, and status (PCOS vs. control) had a significant impact on 2-hour glucose level. However, BMI and waist/hip ratio did not show a significant impact on 2-hour glucose level. Conclusion(s): Chinese women with PCOS are at increased risk for insulin resistance and glucose intolerance compared with controls. Body mass index failed to show significant impact on 2-hour glucose levels in our infertility patients.

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