Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: A community-based survey of 10,602 women

Hui Chi Chen, San Lin You, Chang Yao Hsieh, Mark Schiffman, Ching Yu Lin, Mei Hung Pan, Yi Chun Chou, Kai Li Liaw, Ann W. Hsing, Chien Jen Chen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large-scale community-based cohort study in Taiwan to estimate prevalence of genotype-specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30-65 years old, mean 46.3) in 1991-1992. Genotyping was performed using MY11/GP6+ PCR-based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2% for 10,602 eligible participants, and 13.8% for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5%), HPV16 (2.0%), HPV56 (1.8%), HPV18 (1.6%), HPV33 (1.2%), HPV58 (1.3%) and HPV39 (1.0%). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2%) was most common, followed by HPV58 (25.0%), HPV52 (19.6%), HPV31 (8.9%), HPV33 (8.9%) and HPV18 (3.6%). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high-grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types.

Original languageEnglish
Pages (from-to)1192-1203
Number of pages12
JournalInternational Journal of Cancer
Volume128
Issue number5
DOIs
Publication statusPublished - Mar 1 2011

Fingerprint

Papillomavirus Infections
Taiwan
Genotype
Neoplasms
Vaccines
Informed Consent
Uterine Cervical Neoplasms
Cell Biology
Surveys and Questionnaires
Cohort Studies
Polymerase Chain Reaction
Infection

Keywords

  • cervical neoplasia
  • cohort
  • genotype
  • human papillomavirus
  • impact

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan : A community-based survey of 10,602 women. / Chen, Hui Chi; You, San Lin; Hsieh, Chang Yao; Schiffman, Mark; Lin, Ching Yu; Pan, Mei Hung; Chou, Yi Chun; Liaw, Kai Li; Hsing, Ann W.; Chen, Chien Jen.

In: International Journal of Cancer, Vol. 128, No. 5, 01.03.2011, p. 1192-1203.

Research output: Contribution to journalArticle

Chen, Hui Chi ; You, San Lin ; Hsieh, Chang Yao ; Schiffman, Mark ; Lin, Ching Yu ; Pan, Mei Hung ; Chou, Yi Chun ; Liaw, Kai Li ; Hsing, Ann W. ; Chen, Chien Jen. / Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan : A community-based survey of 10,602 women. In: International Journal of Cancer. 2011 ; Vol. 128, No. 5. pp. 1192-1203.
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abstract = "Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large-scale community-based cohort study in Taiwan to estimate prevalence of genotype-specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30-65 years old, mean 46.3) in 1991-1992. Genotyping was performed using MY11/GP6+ PCR-based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2{\%} for 10,602 eligible participants, and 13.8{\%} for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5{\%}), HPV16 (2.0{\%}), HPV56 (1.8{\%}), HPV18 (1.6{\%}), HPV33 (1.2{\%}), HPV58 (1.3{\%}) and HPV39 (1.0{\%}). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2{\%}) was most common, followed by HPV58 (25.0{\%}), HPV52 (19.6{\%}), HPV31 (8.9{\%}), HPV33 (8.9{\%}) and HPV18 (3.6{\%}). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high-grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40{\%} more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types.",
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