Prevalence of cervical human papillomavirus in Taiwanese women

Cherng Jye Jeng, Ma Lee Ko, Qing Dong Ling, Jenta Shen, Hui Wen Lin, Chii Ruey Tzeng, Chih Ming Ho, Tsai Yen Chien, Su Chee Chen

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Purpose: To define the prevalence rate of cervical human papilloma virus (HPV) using DNA oligonucleotide microarray and its correlation with risk factors in Taiwanese women in metropolitan Taipei. Methods: Thirteen hundred and twenty healthy women, aged 21-65 yr without history of cervical intraepithelial neoplasia (CIN) or carcinoma were included in this prospective study. Pap smear and HPV typing using oligonucleotide microarray were performed for each woman. They were given a standardized questionnaire to obtain information about the risk factors of cervical cancer in Taiwan. Results: The overall HPV positivity was 19.85% and multiple infections were found in 35.84% of the infected group, 7.92% of the whole study population. The younger the subject, the higher was the infection rate and multiple infection rates. The most common HPV types were 16, 18, 58, 52, 51 and 56, which is different from the western world. The sensitivity of the HPV DNA chip in detecting CIN and cervical carcinoma is 97.06%, and 100% in detecting CIN 2 or more lesions. Risk factors for HPV infection include earlier coitarche (P

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalClinical and Investigative Medicine
Volume28
Issue number5
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Medicine(all)

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