Prevalence of atrial fibrillation in patients with brugada syndrome in Taiwan

Jyh Ming Jimmy Juang, Ching Yu Chen, Yen Bin Liu, Lian Yu Lin, Wen Jone Chen, Ling Ping Lai, Chia Ti Tsai, Jiunn Lee Lin

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2 Citations (Scopus)

Abstract

Purpose: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan. Methods: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS. Results: Six BrS patientswere identified with AF, and all of themweremale. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 16 years, similar to those BrS patients without AF (45 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16). Conclusions: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalActa Cardiologica Sinica
Volume29
Issue number4
Publication statusPublished - Jul 1 2013
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Brugada syndrome
  • Taiwan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Juang, J. M. J., Chen, C. Y., Liu, Y. B., Lin, L. Y., Chen, W. J., Lai, L. P., Tsai, C. T., & Lin, J. L. (2013). Prevalence of atrial fibrillation in patients with brugada syndrome in Taiwan. Acta Cardiologica Sinica, 29(4), 311-316.