Prevalence of antimicrobial resistance among clinical isolates of Haemophilus influenzae in Taiwan

Hsiu Chen Lin, Chih Chien Wang, Cheing Mei Yu, Mong Ling Chu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to determine the prevalence of resistance to various antimicrobial drugs among Haemophilus influenzae isolates in Taiwan. Two hundred and ninety-six clinical isolates of H. influenzae were prospectively obtained from nine teaching hospitals throughout Taiwan, from June 1994 to April 1995. All isolates were examined for the presence of type b encapsulation and β-lactamase production. Antibiotic susceptibility was determined by means of standard broth microdilution procedures. Twenty-three isolates (7.8%) were type b, and the overall rate of β-lactamase production was 58.1% (172/296). The rates of resistance to antibiotics were 58.1% for ampicillin, 33.8% for trimethoprim-sulfamethoxazole, 20.6% for chloramphenicol, 27% for tetracycline, 6.7% for azithromycin, 3.4% for cefaclor, and 0.3% for cefuroxime. Cefixime, ceftriaxone, and ciprofloxacin were active against all H. influenzae isolates. Thirty (10.1%) of the 296 isolates were resistant to three drugs (ampicillin, chloramphenicol, and tetracycline), 16 of which (5.4%) were resistant to four drugs (ampicillin, chloramphenicol, tetracycline, and trimethoprimsulfamethoxazole). There was a marked increase in the rates of ampicillin resistance and β-lactamase production among H. influenzae isolates compared with a previous survey in Taiwan conducted 9 years ago. In addition, isolates with multiple drug resistance were also identified. Continued efforts are needed to monitor antibiotic resistance patterns of H. influenzae in the region.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume98
Issue number5
Publication statusPublished - May 1999

Fingerprint

Haemophilus influenzae
Taiwan
Chloramphenicol
Ampicillin
Tetracycline
Microbial Drug Resistance
Pharmaceutical Preparations
Cefixime
Cefaclor
Ampicillin Resistance
Cefuroxime
Azithromycin
Ceftriaxone
Sulfamethoxazole Drug Combination Trimethoprim
Multiple Drug Resistance
Ciprofloxacin
Teaching Hospitals
Anti-Bacterial Agents

Keywords

  • Antimicrobial resistance
  • Beta-lactamase
  • Haemophilus influenzae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence of antimicrobial resistance among clinical isolates of Haemophilus influenzae in Taiwan. / Lin, Hsiu Chen; Wang, Chih Chien; Yu, Cheing Mei; Chu, Mong Ling.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 98, No. 5, 05.1999, p. 319-325.

Research output: Contribution to journalArticle

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abstract = "The purpose of this study was to determine the prevalence of resistance to various antimicrobial drugs among Haemophilus influenzae isolates in Taiwan. Two hundred and ninety-six clinical isolates of H. influenzae were prospectively obtained from nine teaching hospitals throughout Taiwan, from June 1994 to April 1995. All isolates were examined for the presence of type b encapsulation and β-lactamase production. Antibiotic susceptibility was determined by means of standard broth microdilution procedures. Twenty-three isolates (7.8{\%}) were type b, and the overall rate of β-lactamase production was 58.1{\%} (172/296). The rates of resistance to antibiotics were 58.1{\%} for ampicillin, 33.8{\%} for trimethoprim-sulfamethoxazole, 20.6{\%} for chloramphenicol, 27{\%} for tetracycline, 6.7{\%} for azithromycin, 3.4{\%} for cefaclor, and 0.3{\%} for cefuroxime. Cefixime, ceftriaxone, and ciprofloxacin were active against all H. influenzae isolates. Thirty (10.1{\%}) of the 296 isolates were resistant to three drugs (ampicillin, chloramphenicol, and tetracycline), 16 of which (5.4{\%}) were resistant to four drugs (ampicillin, chloramphenicol, tetracycline, and trimethoprimsulfamethoxazole). There was a marked increase in the rates of ampicillin resistance and β-lactamase production among H. influenzae isolates compared with a previous survey in Taiwan conducted 9 years ago. In addition, isolates with multiple drug resistance were also identified. Continued efforts are needed to monitor antibiotic resistance patterns of H. influenzae in the region.",
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