Prevalence of and risk factors for lipodystrophy among HIVinfected patients receiving combined antiretroviral treatment in the Asia-pacific region: Results from the TREAT asia HIV observational database (TAHOD)

Sang Hoon Han, Jialun Zhou, Suneeta Saghayam, Sasheela Vanar, Nittaya Phanuphak, Yi Ming A. Chen, Thira Sirisanthana, Somnuek Sungkanuparph, Christopher K.C. Lee, Sanjay Pujari, Patrick C.K. Li, Shinichi Oka, Vonthanak Saphonn, Fujie Zhang, Tuti Parwati Merati, Matthew G. Law, Jun Yong Choi

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18 Citations (Scopus)

Abstract

The prevalence of and risk factors for lipodystrophy (LD) among patients receiving combined antiretroviral treatment (cART) in the Asia-Pacific region are largely unknown. LD diagnosis was based on the adverse event definition from the US NIH Division of AIDS (2004 version), and only cases with a severity grade of ≥ 3 were included. TAHOD patients who had recently commenced cART with ≥ 3 drugs after 1996 from sites which had ever reported LD were included in the analysis. Covariates for the forward multivariate logistic regression model included demographic variables, CDC disease classification, baseline CD4 and viral load, hepatitis B/C virus co-infection, and regimen and duration of cART. LD was diagnosed in 217 (10.5%) of 2072 patients. The median duration of cART was 3.8 (interquartile range, 2.2-5.3) years (stavudine, 2.0 (1.0-3.5) years; zidovudine, 1.8 (0.6-3.9) years; and protease inhibitors (PI), 2.6 (1.3-4.5) years). In the multivariate model, factors independently associated with LD included use of stavudine (≤ 2 years vs. no experience: OR 25.46, p<0.001, > 2 years vs. no experience: OR 14.92, p<0.001), use of PI (> 2.6 years vs. no experience: OR 0.26, p<0.001), and total duration of cART (> vs. ≤ 3.8 years: OR 4.84, p<0.001). The use of stavudine was strongly associated with LD in our cohort. Stavudine-sparing cART strategies are warranted to prevent the occurrence of LD in the Asia-Pacific region.

Original languageEnglish
Pages (from-to)475-484
Number of pages10
JournalEndocrine Journal
Volume58
Issue number6
DOIs
Publication statusPublished - Jul 11 2011
Externally publishedYes

Keywords

  • Adverse effects
  • Asia-pacific
  • Combined antiretroviral treatment
  • HIV
  • Lipodystrophy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Han, S. H., Zhou, J., Saghayam, S., Vanar, S., Phanuphak, N., Chen, Y. M. A., Sirisanthana, T., Sungkanuparph, S., Lee, C. K. C., Pujari, S., Li, P. C. K., Oka, S., Saphonn, V., Zhang, F., Merati, T. P., Law, M. G., & Choi, J. Y. (2011). Prevalence of and risk factors for lipodystrophy among HIVinfected patients receiving combined antiretroviral treatment in the Asia-pacific region: Results from the TREAT asia HIV observational database (TAHOD). Endocrine Journal, 58(6), 475-484. https://doi.org/10.1507/endocrj.K10E-407