Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: A nation-wide community-based study (HALST cohort)

Jyh Ming Jimmy Juang, Ching Yu Julius Chen, Ying Hsiang Chen, I. Chien Wu, Chih Cheng Hsu, Lei Na Chen, Feng Cheng Tang, Chi Chung Wang, Chung Chou Juan, Hou Chang Chiu, Huey Ming Lo, I. Shou Chang, Juey Jen Hwang, Ling Ping Lai, Fu Tien Chiang, Jiunn-Lee Lin, Chao Agnes Hsiung

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality.

Original languageEnglish
Pages (from-to)ii54-ii62
JournalEuropace
Volume17
DOIs
Publication statusPublished - Feb 28 2015
Externally publishedYes

Keywords

  • Brugada ECG pattern
  • Community-based
  • Han Chinese population
  • Long-term prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Juang, J. M. J., Chen, C. Y. J., Chen, Y. H., Wu, I. C., Hsu, C. C., Chen, L. N., Tang, F. C., Wang, C. C., Juan, C. C., Chiu, H. C., Lo, H. M., Chang, I. S., Hwang, J. J., Lai, L. P., Chiang, F. T., Lin, J-L., & Hsiung, C. A. (2015). Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: A nation-wide community-based study (HALST cohort). Europace, 17, ii54-ii62. https://doi.org/10.1093/europace/euv141