Prevalence and associated risk factors of myopic maculopathy in elderly Chinese

The Shihpai eye study

Shih Jen Chen, Ching Yu Cheng, An Fei Li, Kai Ling Peng, Pesus Chou, Shih Hwa Chiou, Wen Ming Hsu

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To assess the prevalence and associated risk factors of myopic maculopathy in an elderly Chinese population in Taiwan. METHODS. Population-based, cross-sectional study. A total of 1361 Chinese aged 65 years or older residing in Shihpai, Taipei, Taiwan, underwent a detailed ophthalmic examination. Of the 1361 participants, 1058 subjects had at least one gradable fundus photograph and were recruited for analysis. High myopia was defined as spherical equivalent of less than -6.0 diopter (D) in the phakic eyes or axial length greater than 26.5 mm in pseudophakic or aphakic eyes. Myopic maculopathy was defined as the appearance of lacquer cracks, focal area of deep choroidal atrophy and macular choroidal neovascularization, or geographic atrophy in the presence of high myopia. RESULTS. The prevalence of high myopia was 4.2% (44/1058). Signs of myopic maculopathy were present in 32 (72.7%) of the 44 high myopics, representing a prevalence of 3.0% (95% confidence interval, 2.0%-4.0%). Subjects with high myopia with myopic maculopathy had higher systolic blood pressure than those without maculopathy (146.4±16.2 mm Hg vs. 127.0±15.9 mm Hg, P 1/4 0.001), and the difference persisted (P 1/4 0.018) after adjustment for age, sex, smoking, body mass index, diastolic blood pressure, educational levels, alcohol drinking, and histories of diabetes or taking anti-hypertension medication. Of the 65 high myopic eyes, eyes with maculopathy had a greater myopic degree (_12.8±5.1 D vs. _7.6 61.5 D, P 1/4 0.001) and poorer corrected visual acuity (logMAR 0.72±0.6 vs. 0.27±0.2, P 1/4 0.001) than those without. CONCLUSIONS. The prevalence of high myopia and myopic maculopathy in this elderly Chinese population group was high. Of the major risk factors examined, high systolic blood pressure may be associated with myopic maculopathy.

Original languageEnglish
Pages (from-to)4868-4873
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number8
DOIs
Publication statusPublished - Jul 2012

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Myopia
Blood Pressure
Hypertension
Taiwan
Eye Axial Length
Geographic Atrophy
Lacquer
Choroidal Neovascularization
Population Groups
Alcohol Drinking
Population
Visual Acuity
Atrophy
Body Mass Index
Cross-Sectional Studies
Smoking
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Prevalence and associated risk factors of myopic maculopathy in elderly Chinese : The Shihpai eye study. / Chen, Shih Jen; Cheng, Ching Yu; Li, An Fei; Peng, Kai Ling; Chou, Pesus; Chiou, Shih Hwa; Hsu, Wen Ming.

In: Investigative Ophthalmology and Visual Science, Vol. 53, No. 8, 07.2012, p. 4868-4873.

Research output: Contribution to journalArticle

Chen, Shih Jen ; Cheng, Ching Yu ; Li, An Fei ; Peng, Kai Ling ; Chou, Pesus ; Chiou, Shih Hwa ; Hsu, Wen Ming. / Prevalence and associated risk factors of myopic maculopathy in elderly Chinese : The Shihpai eye study. In: Investigative Ophthalmology and Visual Science. 2012 ; Vol. 53, No. 8. pp. 4868-4873.
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T1 - Prevalence and associated risk factors of myopic maculopathy in elderly Chinese

T2 - The Shihpai eye study

AU - Chen, Shih Jen

AU - Cheng, Ching Yu

AU - Li, An Fei

AU - Peng, Kai Ling

AU - Chou, Pesus

AU - Chiou, Shih Hwa

AU - Hsu, Wen Ming

PY - 2012/7

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N2 - PURPOSE. To assess the prevalence and associated risk factors of myopic maculopathy in an elderly Chinese population in Taiwan. METHODS. Population-based, cross-sectional study. A total of 1361 Chinese aged 65 years or older residing in Shihpai, Taipei, Taiwan, underwent a detailed ophthalmic examination. Of the 1361 participants, 1058 subjects had at least one gradable fundus photograph and were recruited for analysis. High myopia was defined as spherical equivalent of less than -6.0 diopter (D) in the phakic eyes or axial length greater than 26.5 mm in pseudophakic or aphakic eyes. Myopic maculopathy was defined as the appearance of lacquer cracks, focal area of deep choroidal atrophy and macular choroidal neovascularization, or geographic atrophy in the presence of high myopia. RESULTS. The prevalence of high myopia was 4.2% (44/1058). Signs of myopic maculopathy were present in 32 (72.7%) of the 44 high myopics, representing a prevalence of 3.0% (95% confidence interval, 2.0%-4.0%). Subjects with high myopia with myopic maculopathy had higher systolic blood pressure than those without maculopathy (146.4±16.2 mm Hg vs. 127.0±15.9 mm Hg, P 1/4 0.001), and the difference persisted (P 1/4 0.018) after adjustment for age, sex, smoking, body mass index, diastolic blood pressure, educational levels, alcohol drinking, and histories of diabetes or taking anti-hypertension medication. Of the 65 high myopic eyes, eyes with maculopathy had a greater myopic degree (_12.8±5.1 D vs. _7.6 61.5 D, P 1/4 0.001) and poorer corrected visual acuity (logMAR 0.72±0.6 vs. 0.27±0.2, P 1/4 0.001) than those without. CONCLUSIONS. The prevalence of high myopia and myopic maculopathy in this elderly Chinese population group was high. Of the major risk factors examined, high systolic blood pressure may be associated with myopic maculopathy.

AB - PURPOSE. To assess the prevalence and associated risk factors of myopic maculopathy in an elderly Chinese population in Taiwan. METHODS. Population-based, cross-sectional study. A total of 1361 Chinese aged 65 years or older residing in Shihpai, Taipei, Taiwan, underwent a detailed ophthalmic examination. Of the 1361 participants, 1058 subjects had at least one gradable fundus photograph and were recruited for analysis. High myopia was defined as spherical equivalent of less than -6.0 diopter (D) in the phakic eyes or axial length greater than 26.5 mm in pseudophakic or aphakic eyes. Myopic maculopathy was defined as the appearance of lacquer cracks, focal area of deep choroidal atrophy and macular choroidal neovascularization, or geographic atrophy in the presence of high myopia. RESULTS. The prevalence of high myopia was 4.2% (44/1058). Signs of myopic maculopathy were present in 32 (72.7%) of the 44 high myopics, representing a prevalence of 3.0% (95% confidence interval, 2.0%-4.0%). Subjects with high myopia with myopic maculopathy had higher systolic blood pressure than those without maculopathy (146.4±16.2 mm Hg vs. 127.0±15.9 mm Hg, P 1/4 0.001), and the difference persisted (P 1/4 0.018) after adjustment for age, sex, smoking, body mass index, diastolic blood pressure, educational levels, alcohol drinking, and histories of diabetes or taking anti-hypertension medication. Of the 65 high myopic eyes, eyes with maculopathy had a greater myopic degree (_12.8±5.1 D vs. _7.6 61.5 D, P 1/4 0.001) and poorer corrected visual acuity (logMAR 0.72±0.6 vs. 0.27±0.2, P 1/4 0.001) than those without. CONCLUSIONS. The prevalence of high myopia and myopic maculopathy in this elderly Chinese population group was high. Of the major risk factors examined, high systolic blood pressure may be associated with myopic maculopathy.

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