Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan: The Shihpai Eye Study

Shih Jen Chen, Ching Yu Cheng, Kai Ling Peng, An Fei Li, Wen-Ming Hsu, Jorn Hon Liu, Pesus Chou

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

PURPOSE. To assess the prevalence and associated risk factors of age-related macular degeneration (AMD) in an elderly Chinese population in Taiwan. METHODS. The Shihpai Eye Study was a survey of vision and ocular disease in an elderly Chinese population 65 years of age or older residing in Shihpai, Taipei, Taiwan. Of 2045 elderly residents randomly sampled from the household registration databank, 1361 (66.6%) underwent a detailed ophthalmic examination that included fundus color slides by fundus camera after pupil dilatation. Photographs were graded according to the Wisconsin Age-Related Maculopathy Grading System. RESULTS. Fundus photographs were available for 1105 (54.0% in the eligible, 81.2% in the ocular examined) participants. The 47 (4.3%) participants who had ungradable fundus images were older and had more lens opacity. Of the 1058 gradable photographs, the prevalence of early AMD was 9.2% (95% confidence interval [CI], 7.8-10.8); of late AMD, 1.9% (95% CI, 1.3-2.7); of soft drusen, 42.2% (95% CI, 39.7-44.8); of soft indistinct drusen, 4.1% (95% CI, 3.1-5.2); and of any pigmentary change, 8.6% (95% CI, 7.2-10.2). Age was the most significant factor associated with both early and late AMD. The prevalence of early AMD rose from 5.0% in the 65- to 69-year age group to 24.4% in those 80 years of age and older; and for late AMD, from 1.0% to 9.0%. Those who currently drank alcohol had a lower rate of early AMD than did the nondrinker (adjusted odd ratio 0.32, 95% CI: 0.11-0.93, P = 0.037). CONCLUSIONS. AMD is a common eye disease in the elderly Chinese people in Taiwan. The adjusted prevalence rate of exudative AMD is comparable to that in the Chinese people in the Multiethnic Study of Atherosclerosis (MESA) in the United States but is higher than in the Chinese people in the Beijing study in China. Further studies are needed to clarify the incidence and associated risk factors.

Original languageEnglish
Pages (from-to)3126-3133
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

Fingerprint

Macular Degeneration
Taiwan
Population
Confidence Intervals
Eye Diseases
Pupil
Cataract
Dilatation
China
Atherosclerosis
Age Groups
Color
Odds Ratio
Alcohols
Databases
Incidence

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan : The Shihpai Eye Study. / Chen, Shih Jen; Cheng, Ching Yu; Peng, Kai Ling; Li, An Fei; Hsu, Wen-Ming; Liu, Jorn Hon; Chou, Pesus.

In: Investigative Ophthalmology and Visual Science, Vol. 49, No. 7, 01.07.2008, p. 3126-3133.

Research output: Contribution to journalArticle

Chen, Shih Jen ; Cheng, Ching Yu ; Peng, Kai Ling ; Li, An Fei ; Hsu, Wen-Ming ; Liu, Jorn Hon ; Chou, Pesus. / Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan : The Shihpai Eye Study. In: Investigative Ophthalmology and Visual Science. 2008 ; Vol. 49, No. 7. pp. 3126-3133.
@article{2c81e4e0d7ba42618c34ff35d484298a,
title = "Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan: The Shihpai Eye Study",
abstract = "PURPOSE. To assess the prevalence and associated risk factors of age-related macular degeneration (AMD) in an elderly Chinese population in Taiwan. METHODS. The Shihpai Eye Study was a survey of vision and ocular disease in an elderly Chinese population 65 years of age or older residing in Shihpai, Taipei, Taiwan. Of 2045 elderly residents randomly sampled from the household registration databank, 1361 (66.6{\%}) underwent a detailed ophthalmic examination that included fundus color slides by fundus camera after pupil dilatation. Photographs were graded according to the Wisconsin Age-Related Maculopathy Grading System. RESULTS. Fundus photographs were available for 1105 (54.0{\%} in the eligible, 81.2{\%} in the ocular examined) participants. The 47 (4.3{\%}) participants who had ungradable fundus images were older and had more lens opacity. Of the 1058 gradable photographs, the prevalence of early AMD was 9.2{\%} (95{\%} confidence interval [CI], 7.8-10.8); of late AMD, 1.9{\%} (95{\%} CI, 1.3-2.7); of soft drusen, 42.2{\%} (95{\%} CI, 39.7-44.8); of soft indistinct drusen, 4.1{\%} (95{\%} CI, 3.1-5.2); and of any pigmentary change, 8.6{\%} (95{\%} CI, 7.2-10.2). Age was the most significant factor associated with both early and late AMD. The prevalence of early AMD rose from 5.0{\%} in the 65- to 69-year age group to 24.4{\%} in those 80 years of age and older; and for late AMD, from 1.0{\%} to 9.0{\%}. Those who currently drank alcohol had a lower rate of early AMD than did the nondrinker (adjusted odd ratio 0.32, 95{\%} CI: 0.11-0.93, P = 0.037). CONCLUSIONS. AMD is a common eye disease in the elderly Chinese people in Taiwan. The adjusted prevalence rate of exudative AMD is comparable to that in the Chinese people in the Multiethnic Study of Atherosclerosis (MESA) in the United States but is higher than in the Chinese people in the Beijing study in China. Further studies are needed to clarify the incidence and associated risk factors.",
author = "Chen, {Shih Jen} and Cheng, {Ching Yu} and Peng, {Kai Ling} and Li, {An Fei} and Wen-Ming Hsu and Liu, {Jorn Hon} and Pesus Chou",
year = "2008",
month = "7",
day = "1",
doi = "10.1167/iovs.08-1803",
language = "English",
volume = "49",
pages = "3126--3133",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "7",

}

TY - JOUR

T1 - Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan

T2 - The Shihpai Eye Study

AU - Chen, Shih Jen

AU - Cheng, Ching Yu

AU - Peng, Kai Ling

AU - Li, An Fei

AU - Hsu, Wen-Ming

AU - Liu, Jorn Hon

AU - Chou, Pesus

PY - 2008/7/1

Y1 - 2008/7/1

N2 - PURPOSE. To assess the prevalence and associated risk factors of age-related macular degeneration (AMD) in an elderly Chinese population in Taiwan. METHODS. The Shihpai Eye Study was a survey of vision and ocular disease in an elderly Chinese population 65 years of age or older residing in Shihpai, Taipei, Taiwan. Of 2045 elderly residents randomly sampled from the household registration databank, 1361 (66.6%) underwent a detailed ophthalmic examination that included fundus color slides by fundus camera after pupil dilatation. Photographs were graded according to the Wisconsin Age-Related Maculopathy Grading System. RESULTS. Fundus photographs were available for 1105 (54.0% in the eligible, 81.2% in the ocular examined) participants. The 47 (4.3%) participants who had ungradable fundus images were older and had more lens opacity. Of the 1058 gradable photographs, the prevalence of early AMD was 9.2% (95% confidence interval [CI], 7.8-10.8); of late AMD, 1.9% (95% CI, 1.3-2.7); of soft drusen, 42.2% (95% CI, 39.7-44.8); of soft indistinct drusen, 4.1% (95% CI, 3.1-5.2); and of any pigmentary change, 8.6% (95% CI, 7.2-10.2). Age was the most significant factor associated with both early and late AMD. The prevalence of early AMD rose from 5.0% in the 65- to 69-year age group to 24.4% in those 80 years of age and older; and for late AMD, from 1.0% to 9.0%. Those who currently drank alcohol had a lower rate of early AMD than did the nondrinker (adjusted odd ratio 0.32, 95% CI: 0.11-0.93, P = 0.037). CONCLUSIONS. AMD is a common eye disease in the elderly Chinese people in Taiwan. The adjusted prevalence rate of exudative AMD is comparable to that in the Chinese people in the Multiethnic Study of Atherosclerosis (MESA) in the United States but is higher than in the Chinese people in the Beijing study in China. Further studies are needed to clarify the incidence and associated risk factors.

AB - PURPOSE. To assess the prevalence and associated risk factors of age-related macular degeneration (AMD) in an elderly Chinese population in Taiwan. METHODS. The Shihpai Eye Study was a survey of vision and ocular disease in an elderly Chinese population 65 years of age or older residing in Shihpai, Taipei, Taiwan. Of 2045 elderly residents randomly sampled from the household registration databank, 1361 (66.6%) underwent a detailed ophthalmic examination that included fundus color slides by fundus camera after pupil dilatation. Photographs were graded according to the Wisconsin Age-Related Maculopathy Grading System. RESULTS. Fundus photographs were available for 1105 (54.0% in the eligible, 81.2% in the ocular examined) participants. The 47 (4.3%) participants who had ungradable fundus images were older and had more lens opacity. Of the 1058 gradable photographs, the prevalence of early AMD was 9.2% (95% confidence interval [CI], 7.8-10.8); of late AMD, 1.9% (95% CI, 1.3-2.7); of soft drusen, 42.2% (95% CI, 39.7-44.8); of soft indistinct drusen, 4.1% (95% CI, 3.1-5.2); and of any pigmentary change, 8.6% (95% CI, 7.2-10.2). Age was the most significant factor associated with both early and late AMD. The prevalence of early AMD rose from 5.0% in the 65- to 69-year age group to 24.4% in those 80 years of age and older; and for late AMD, from 1.0% to 9.0%. Those who currently drank alcohol had a lower rate of early AMD than did the nondrinker (adjusted odd ratio 0.32, 95% CI: 0.11-0.93, P = 0.037). CONCLUSIONS. AMD is a common eye disease in the elderly Chinese people in Taiwan. The adjusted prevalence rate of exudative AMD is comparable to that in the Chinese people in the Multiethnic Study of Atherosclerosis (MESA) in the United States but is higher than in the Chinese people in the Beijing study in China. Further studies are needed to clarify the incidence and associated risk factors.

UR - http://www.scopus.com/inward/record.url?scp=48249145146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48249145146&partnerID=8YFLogxK

U2 - 10.1167/iovs.08-1803

DO - 10.1167/iovs.08-1803

M3 - Article

C2 - 18390643

AN - SCOPUS:48249145146

VL - 49

SP - 3126

EP - 3133

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 7

ER -