Pretreatment with an ethanolic extract of Taiwanofungus camphoratus (Antrodia camphorata) enhances the cytotoxic effects of amphotericin B

Ling Yi Chen, Ming Thau Sheu, Der Zen Liu, Chuh Kai Liao, Hsiu O. Ho, Woei Yao Kao, Yaun Soon Ho, Wen Sen Lee, Ching-Hua Su

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Taiwanofungus camphoratus, a well-known Chinese medicine used in Taiwan, possesses several pharmacological functions, including anticancer effects. In the present study, we aimed to investigate a novel anticancer effect by pretreating cancer cells with an ethanolic extract of T. camphoratus (TCEE) followed by the administration of an antifungal agent amphotericin B (AmB). Both TCEE and AmB showed significant dose-dependent cytotoxicity in HT29 cells. Pretreatment with a nontoxic dose of TCEE enhanced the cytotoxicity of AmB. Furthermore, significant apoptotic cell death was found in cells treated with TCEE and AmB. A combination treatment with AmB plus TCEE resulted in a significant repression of tumor growth in HT29 xenografts. Collectively, our results indicated that combined treatment with AmB and TCEE effectively induced apoptosis and inhibited tumor growth. In the future, TCEE may serve as a potential complementary and alternative medicine to treat patients suffering from colorectal cancer.

Original languageEnglish
Pages (from-to)11255-11263
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number20
DOIs
Publication statusPublished - Oct 26 2011

Keywords

  • amphotericin B
  • antifungal agents
  • Antrodia camphorata
  • apoptosis
  • colon cancer
  • Taiwanofungus camphoratus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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