Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Cheng Jeng Tai, Ching Fong Liao, Tzu Cheng Su, Ko Hung Shen, Chun Chao Chang, Shu Hui Lin, Chung Min Yeh, Shing Chuan Shen, Woan Ruoh Lee, Jeng Fong Chiou, Chih Hung Lin, Ying Chun Chen, Hsin Yi Shih, Kun Tu Yeh, Ming Chung Jiang

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6 Citations (Scopus)

Abstract

The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

Original languageEnglish
JournalInternational Journal of Biological Markers
Volume27
Issue number3
DOIs
Publication statusPublished - Jul 2012

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Keywords

  • Bladder cancer
  • Tumor markers
  • Urine
  • Urothelial carcinomas

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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