Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Cheng Jeng Tai, Ching Fong Liao, Tzu Cheng Su, Ko Hung Shen, Chun Chao Chang, Shu Hui Lin, Chung Min Yeh, Shing Chuan Shen, Woan Ruoh Lee, Jeng Fong Chiou, Chih Hung Lin, Ying Chun Chen, Hsin Yi Shih, Kun Tu Yeh, Ming Chung Jiang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

Original languageEnglish
JournalInternational Journal of Biological Markers
Volume27
Issue number3
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Cellular Apoptosis Susceptibility Protein
Chromosome Segregation
Chromosomes, Human, Pair 1
Chromosomes
Urinary Bladder
Urine
Carcinoma
Urinary Bladder Neoplasms
Immunoblotting
Tumors
Neoplasms
Cells
Staining and Labeling

Keywords

  • Bladder cancer
  • Tumor markers
  • Urine
  • Urothelial carcinomas

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas. / Tai, Cheng Jeng; Liao, Ching Fong; Su, Tzu Cheng; Shen, Ko Hung; Chang, Chun Chao; Lin, Shu Hui; Yeh, Chung Min; Shen, Shing Chuan; Lee, Woan Ruoh; Chiou, Jeng Fong; Lin, Chih Hung; Chen, Ying Chun; Shih, Hsin Yi; Yeh, Kun Tu; Jiang, Ming Chung.

In: International Journal of Biological Markers, Vol. 27, No. 3, 07.2012.

Research output: Contribution to journalArticle

Tai, Cheng Jeng ; Liao, Ching Fong ; Su, Tzu Cheng ; Shen, Ko Hung ; Chang, Chun Chao ; Lin, Shu Hui ; Yeh, Chung Min ; Shen, Shing Chuan ; Lee, Woan Ruoh ; Chiou, Jeng Fong ; Lin, Chih Hung ; Chen, Ying Chun ; Shih, Hsin Yi ; Yeh, Kun Tu ; Jiang, Ming Chung. / Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas. In: International Journal of Biological Markers. 2012 ; Vol. 27, No. 3.
@article{272c222636e445c393a2eb7edb4dbbac,
title = "Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas",
abstract = "The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95{\%} (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p",
keywords = "Bladder cancer, Tumor markers, Urine, Urothelial carcinomas",
author = "Tai, {Cheng Jeng} and Liao, {Ching Fong} and Su, {Tzu Cheng} and Shen, {Ko Hung} and Chang, {Chun Chao} and Lin, {Shu Hui} and Yeh, {Chung Min} and Shen, {Shing Chuan} and Lee, {Woan Ruoh} and Chiou, {Jeng Fong} and Lin, {Chih Hung} and Chen, {Ying Chun} and Shih, {Hsin Yi} and Yeh, {Kun Tu} and Jiang, {Ming Chung}",
year = "2012",
month = "7",
doi = "10.5301/JBM.2012.9310",
language = "English",
volume = "27",
journal = "International Journal of Biological Markers",
issn = "0393-6155",
publisher = "Wichtig Publishing",
number = "3",

}

TY - JOUR

T1 - Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

AU - Tai, Cheng Jeng

AU - Liao, Ching Fong

AU - Su, Tzu Cheng

AU - Shen, Ko Hung

AU - Chang, Chun Chao

AU - Lin, Shu Hui

AU - Yeh, Chung Min

AU - Shen, Shing Chuan

AU - Lee, Woan Ruoh

AU - Chiou, Jeng Fong

AU - Lin, Chih Hung

AU - Chen, Ying Chun

AU - Shih, Hsin Yi

AU - Yeh, Kun Tu

AU - Jiang, Ming Chung

PY - 2012/7

Y1 - 2012/7

N2 - The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

AB - The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p

KW - Bladder cancer

KW - Tumor markers

KW - Urine

KW - Urothelial carcinomas

UR - http://www.scopus.com/inward/record.url?scp=84867527408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867527408&partnerID=8YFLogxK

U2 - 10.5301/JBM.2012.9310

DO - 10.5301/JBM.2012.9310

M3 - Article

C2 - 22653741

AN - SCOPUS:84867527408

VL - 27

JO - International Journal of Biological Markers

JF - International Journal of Biological Markers

SN - 0393-6155

IS - 3

ER -