Prescriptions for category D and X drugs during pregnancy in Taiwan: A population-based study

Li Ting Kao, Yi Hua Chen, Herng Ching Lin, Shiu Dong Chung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: This study aimed to investigate the most prescribed medications and principle diagnoses for category D and X drugs during pregnancy using a population-based dataset in Taiwan. Methods: The data for the present study were sourced from the Taiwan Longitudinal Health Insurance Database 2000. We selected 14125 women who had live singleton births between 1 January 2009 and 31 December 2011. In total, 217226 prescriptions prescribed to these pregnant women were identified. Results: Of the total 217226 prescriptions, 1.1% were category D or X drugs; in the first, second, and third trimesters of pregnancy, 1.8%, 0.7%, and 0.5% of prescriptions were category D or X drugs, respectively. Progestins (15.3%) and propylthiouracil (10.7%) were the two most frequently prescribed category D or X drugs during pregnancy. In particular, progestins (20.4%) and estrogens (15.6%) were the most frequently prescribed category D or X drug in the first trimester of pregnancy. Propylthiouracil was the most prescribed category D or X drug in the second (20.3%) and third trimesters (23.1%) of pregnancy, respectively. The most common principal diagnosis during pregnancy was "disorders of menstruation and other abnormal bleeding from the female genital tract" (22% of all principal diagnoses for prescribing category D and X drugs). Conclusions: Our study found that the physicians obviously reduced the use of category D and X drugs for women after becoming aware that they were pregnant. Copyright

Original languageEnglish
Pages (from-to)1029-1034
Number of pages6
JournalPharmacoepidemiology and Drug Safety
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Taiwan
Prescriptions
Pregnancy
Pharmaceutical Preparations
Population
Propylthiouracil
Third Pregnancy Trimester
Second Pregnancy Trimester
Progestins
First Pregnancy Trimester
Menstruation Disturbances
Live Birth
Health Insurance
Pregnant Women
Estrogens
Databases
Hemorrhage
Physicians

Keywords

  • Category D and X drugs
  • Pharmacoepidemiology
  • Pregnancy
  • Prescribing behavior

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Epidemiology
  • Medicine(all)

Cite this

Prescriptions for category D and X drugs during pregnancy in Taiwan : A population-based study. / Kao, Li Ting; Chen, Yi Hua; Lin, Herng Ching; Chung, Shiu Dong.

In: Pharmacoepidemiology and Drug Safety, Vol. 23, No. 10, 01.10.2014, p. 1029-1034.

Research output: Contribution to journalArticle

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