Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects

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Abstract

Aims: To determine the effect of an oral dose of sitagliptin on the secretion of ghrelin and gastrin hormones. Methods: Ten healthy volunteers were recruited in this study. A baseline blood sample was drawn before oral dosing with a 100-mg tablet of sitagliptin. Two blood samples were obtained 0.5 and 1 h after dosing. Three additional postprandial blood samples were drawn at 0.5, 1, and 2 h. Radioimmunoassay was used for determining hormonal levels. A Student's t test, Pearson correlation analysis, and multivariate approach to repeated-measures analysis of variance were used for statistics. Results: After sitagliptin dosing, but before the meal, there was no significant change in circulating ghrelin, gastrin, insulin, and glucose levels. Only after meal loading was there a progressive and persistent decline in ghrelin levels until the end of the study, while a rapid and temporary rise in gastrin, insulin, and glucose levels at 0.5 h was observed. The levels of gastrin, insulin, and glucose then declined progressively. Conclusions: Preprandial oral dose of sitagliptin does not affect circulating ghrelin, gastrin, insulin, and glucose concentrations in normal subjects. Decreased ghrelin and increased gastrin and insulin levels occurred only after meal loading. These results support the theory that sitagliptin might not cause appetite-enhanced body weight gain and insulin-induced hypoglycemia.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalPharmacology
Volume85
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Ghrelin
Gastrins
Insulin
Meals
Glucose
Appetite
Hypoglycemia
Tablets
Weight Gain
Radioimmunoassay
Sitagliptin Phosphate
Analysis of Variance
Healthy Volunteers
Multivariate Analysis
Body Weight
Hormones
Students

Keywords

  • Gastrin
  • Ghrelin
  • Insulin
  • Sitagliptin

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects",
abstract = "Aims: To determine the effect of an oral dose of sitagliptin on the secretion of ghrelin and gastrin hormones. Methods: Ten healthy volunteers were recruited in this study. A baseline blood sample was drawn before oral dosing with a 100-mg tablet of sitagliptin. Two blood samples were obtained 0.5 and 1 h after dosing. Three additional postprandial blood samples were drawn at 0.5, 1, and 2 h. Radioimmunoassay was used for determining hormonal levels. A Student's t test, Pearson correlation analysis, and multivariate approach to repeated-measures analysis of variance were used for statistics. Results: After sitagliptin dosing, but before the meal, there was no significant change in circulating ghrelin, gastrin, insulin, and glucose levels. Only after meal loading was there a progressive and persistent decline in ghrelin levels until the end of the study, while a rapid and temporary rise in gastrin, insulin, and glucose levels at 0.5 h was observed. The levels of gastrin, insulin, and glucose then declined progressively. Conclusions: Preprandial oral dose of sitagliptin does not affect circulating ghrelin, gastrin, insulin, and glucose concentrations in normal subjects. Decreased ghrelin and increased gastrin and insulin levels occurred only after meal loading. These results support the theory that sitagliptin might not cause appetite-enhanced body weight gain and insulin-induced hypoglycemia.",
keywords = "Gastrin, Ghrelin, Insulin, Sitagliptin",
author = "Chen-Ling Huang and Chung-Huei Hsu and Kuo-Cherh Huang and Su, {Hsiu Yueh} and Weng, {S. F.}",
year = "2010",
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T1 - Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects

AU - Huang, Chen-Ling

AU - Hsu, Chung-Huei

AU - Huang, Kuo-Cherh

AU - Su, Hsiu Yueh

AU - Weng, S. F.

PY - 2010/3

Y1 - 2010/3

N2 - Aims: To determine the effect of an oral dose of sitagliptin on the secretion of ghrelin and gastrin hormones. Methods: Ten healthy volunteers were recruited in this study. A baseline blood sample was drawn before oral dosing with a 100-mg tablet of sitagliptin. Two blood samples were obtained 0.5 and 1 h after dosing. Three additional postprandial blood samples were drawn at 0.5, 1, and 2 h. Radioimmunoassay was used for determining hormonal levels. A Student's t test, Pearson correlation analysis, and multivariate approach to repeated-measures analysis of variance were used for statistics. Results: After sitagliptin dosing, but before the meal, there was no significant change in circulating ghrelin, gastrin, insulin, and glucose levels. Only after meal loading was there a progressive and persistent decline in ghrelin levels until the end of the study, while a rapid and temporary rise in gastrin, insulin, and glucose levels at 0.5 h was observed. The levels of gastrin, insulin, and glucose then declined progressively. Conclusions: Preprandial oral dose of sitagliptin does not affect circulating ghrelin, gastrin, insulin, and glucose concentrations in normal subjects. Decreased ghrelin and increased gastrin and insulin levels occurred only after meal loading. These results support the theory that sitagliptin might not cause appetite-enhanced body weight gain and insulin-induced hypoglycemia.

AB - Aims: To determine the effect of an oral dose of sitagliptin on the secretion of ghrelin and gastrin hormones. Methods: Ten healthy volunteers were recruited in this study. A baseline blood sample was drawn before oral dosing with a 100-mg tablet of sitagliptin. Two blood samples were obtained 0.5 and 1 h after dosing. Three additional postprandial blood samples were drawn at 0.5, 1, and 2 h. Radioimmunoassay was used for determining hormonal levels. A Student's t test, Pearson correlation analysis, and multivariate approach to repeated-measures analysis of variance were used for statistics. Results: After sitagliptin dosing, but before the meal, there was no significant change in circulating ghrelin, gastrin, insulin, and glucose levels. Only after meal loading was there a progressive and persistent decline in ghrelin levels until the end of the study, while a rapid and temporary rise in gastrin, insulin, and glucose levels at 0.5 h was observed. The levels of gastrin, insulin, and glucose then declined progressively. Conclusions: Preprandial oral dose of sitagliptin does not affect circulating ghrelin, gastrin, insulin, and glucose concentrations in normal subjects. Decreased ghrelin and increased gastrin and insulin levels occurred only after meal loading. These results support the theory that sitagliptin might not cause appetite-enhanced body weight gain and insulin-induced hypoglycemia.

KW - Gastrin

KW - Ghrelin

KW - Insulin

KW - Sitagliptin

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