Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles

Tzu Hui Wu, Feng Lin Yen, Liang Tzung Lin, Tong Rong Tsai, Chun Ching Lin, Thau Ming Cham

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

The purpose of this study was to develop quercetin-loaded nanoparticles (QUEN) by a nanoprecipitation technique with Eudragit® E (EE) and polyvinyl alcohol (PVA) as carriers, and to evaluate the antioxidant effects of quercetin (QU) and of its nanoparticles. The novel QUEN systems were characterized by particle size and morphology, yield and encapsulation efficiency, differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance (1H NMR), and dissolution study. It was observed that the weight ratio of QU:EE:PVA at 1:10:10 carried a particle size of 1H NMR demonstrated that QU formed intermolecular hydrogen bonding with carriers. The release of the drug from the QUEN was 74-fold higher compared with the pure drug. In addition, the antioxidant activity of the QUEN was more effective than pure QU on DPPH scavenging, anti-superoxide formation, superoxide anion scavenging, and anti-lipid peroxidation.

Original languageEnglish
Pages (from-to)160-168
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume346
Issue number1-2
DOIs
Publication statusPublished - Jan 4 2008
Externally publishedYes

Fingerprint

Quercetin
Nanoparticles
Antioxidants
Polyvinyl Alcohol
Particle Size
Superoxides
Magnetic Resonance Spectroscopy
Differential Scanning Calorimetry
Fourier Transform Infrared Spectroscopy
Hydrogen Bonding
X-Ray Diffraction
Powders
Lipid Peroxidation
Weights and Measures
Pharmaceutical Preparations

Keywords

  • H nuclear magnetic resonance
  • Anti-lipid peroxidation
  • Free radical-scavenging activity
  • Nanoparticles
  • Quercetin

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. / Wu, Tzu Hui; Yen, Feng Lin; Lin, Liang Tzung; Tsai, Tong Rong; Lin, Chun Ching; Cham, Thau Ming.

In: International Journal of Pharmaceutics, Vol. 346, No. 1-2, 04.01.2008, p. 160-168.

Research output: Contribution to journalArticle

Wu, Tzu Hui ; Yen, Feng Lin ; Lin, Liang Tzung ; Tsai, Tong Rong ; Lin, Chun Ching ; Cham, Thau Ming. / Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. In: International Journal of Pharmaceutics. 2008 ; Vol. 346, No. 1-2. pp. 160-168.
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