Preparation of improved bioactive tissue adhesives using autologous human thrombin

C. Y. Su, T. Burnouf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The two types of bioactive tissue adhesives were prepared by using autologous human thrombin. The clotting times as well as the levels of platelet-derived growth factor (PDGF-AB) and transforming growth factor-β1 (TGF-β1) of platelet gels, obtained from PRP mixed with either bovine thrombin (BT) or autologous human thrombin (AHT), were compared. It was suggested that AHT is more potent trigger for granule secretion and growth factors release than BT, and is a suitable agent to activate PRP to prepare 100% autologous bioactive platelet gel. The use of AHT would avoid the immunological and infectious risks potentially associated to BT. AHT can be prepared with the plasma from the same donor using a specially designed reaction device.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1652
Number of pages1
Publication statusPublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Su, C. Y., & Burnouf, T. (2004). Preparation of improved bioactive tissue adhesives using autologous human thrombin. In Transactions - 7th World Biomaterials Congress (pp. 1652)