Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Ming Chien Yang, Yi Qun Tseng, Kun Ho Liu, Yu Wei Cheng, Wan Tzu Chen, Wei Ting Chen, Chia Wei Hsiao, Ming Chi Yung, Chuan Chih Hsu, Ting Yu Liu

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1 Citation (Scopus)


Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

Original languageEnglish
Article number3051
JournalApplied Sciences (Switzerland)
Issue number15
Publication statusPublished - Jan 1 2019



  • Amphiphatic chitosan
  • Antibacterial ability
  • Cellulose nanocrystals
  • Graphene oxide
  • Nanocomposite hydrogel

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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