Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Ming Chien Yang; Yi Qun Tseng; Kun Ho Liu; Yu Wei Cheng; Wan Tzu Chen; Wei Ting Chen; Chia Wei Hsiao; Ming Chi Yung; Chuan Chih Hsu; Ting Yu Liu

doi:10.3390/app9153051

Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Ming Chien Yang, Yi Qun Tseng, Kun Ho Liu, Yu Wei Cheng, Wan Tzu Chen, Wei Ting Chen, Chia Wei Hsiao, Ming Chi Yung, Chuan Chih Hsu, Ting Yu Liu

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

Original language	English
Article number	3051
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	15
DOIs	https://doi.org/10.3390/app9153051
Publication status	Published - Jan 1 2019

Keywords

Amphiphatic chitosan
Antibacterial ability
Cellulose nanocrystals
Graphene oxide
Nanocomposite hydrogel

ASJC Scopus subject areas

Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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Yang, M. C., Tseng, Y. Q., Liu, K. H., Cheng, Y. W., Chen, W. T., Chen, W. T., Hsiao, C. W., Yung, M. C., Hsu, C. C., & Liu, T. Y. (2019). Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties. Applied Sciences (Switzerland), 9(15), [3051]. https://doi.org/10.3390/app9153051

Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties. / Yang, Ming Chien; Tseng, Yi Qun; Liu, Kun Ho; Cheng, Yu Wei; Chen, Wan Tzu; Chen, Wei Ting; Hsiao, Chia Wei; Yung, Ming Chi; Hsu, Chuan Chih; Liu, Ting Yu.

In: Applied Sciences (Switzerland), Vol. 9, No. 15, 3051, 01.01.2019.

Research output: Contribution to journal › Article › peer-review

Yang, Ming Chien ; Tseng, Yi Qun ; Liu, Kun Ho ; Cheng, Yu Wei ; Chen, Wan Tzu ; Chen, Wei Ting ; Hsiao, Chia Wei ; Yung, Ming Chi ; Hsu, Chuan Chih ; Liu, Ting Yu. / Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties. In: Applied Sciences (Switzerland). 2019 ; Vol. 9, No. 15.

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abstract = "Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.",

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AB - Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

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