Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Ming Chien Yang; Yi Qun Tseng; Kun Ho Liu; Yu Wei Cheng; Wan Tzu Chen; Wei Ting Chen; Chia Wei Hsiao; Ming Chi Yung; Chuan Chih Hsu; Ting Yu Liu

doi:10.3390/app9153051

Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Ming Chien Yang, Yi Qun Tseng, Kun Ho Liu, Yu Wei Cheng, Wan Tzu Chen, Wei Ting Chen, Chia Wei Hsiao, Ming Chi Yung, Chuan Chih Hsu, Ting Yu Liu

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

Original language	English
Article number	3051
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	15
DOIs	https://doi.org/10.3390/app9153051
Publication status	Published - Jan 1 2019

Keywords

Amphiphatic chitosan
Antibacterial ability
Cellulose nanocrystals
Graphene oxide
Nanocomposite hydrogel

ASJC Scopus subject areas

Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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10.3390/app9153051

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Yang, M. C., Tseng, Y. Q., Liu, K. H., Cheng, Y. W., Chen, W. T., Chen, W. T., Hsiao, C. W., Yung, M. C., Hsu, C. C., & Liu, T. Y. (2019). Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties. Applied Sciences (Switzerland), 9(15), [3051]. https://doi.org/10.3390/app9153051

@article{110562bbcd5f482bace5d4087858a140,

title = "Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties",

abstract = "Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.",

keywords = "Amphiphatic chitosan, Antibacterial ability, Cellulose nanocrystals, Graphene oxide, Nanocomposite hydrogel",

author = "Yang, {Ming Chien} and Tseng, {Yi Qun} and Liu, {Kun Ho} and Cheng, {Yu Wei} and Chen, {Wan Tzu} and Chen, {Wei Ting} and Hsiao, {Chia Wei} and Yung, {Ming Chi} and Hsu, {Chuan Chih} and Liu, {Ting Yu}",

note = "Funding Information: This research and the APC was funded by the Ministry of Science and Technology, Taiwan (MOST 108-2218-E-002-010; MOST 107-2622-8-131-003; MOST 108-2622-E-131-002-CC3), and the industrial development bureau, Ministry of Economic Affairs of Taiwan (E10700010006-059, Conventional Industry Technology Development Plan). We are grateful to the staff of Technology Commons, College of Life Science, Nation Taiwan University (NTU) for help with transmission electron microscopy (TEM), and facilities support byWei-Bor Tsai and Ying-Chih Liao from the Department of Chemical Engineering, NTU. Publisher Copyright: {\textcopyright} 2019 by the authors.",

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doi = "10.3390/app9153051",

language = "English",

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T1 - Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

AU - Yang, Ming Chien

AU - Tseng, Yi Qun

AU - Liu, Kun Ho

AU - Cheng, Yu Wei

AU - Chen, Wan Tzu

AU - Chen, Wei Ting

AU - Hsiao, Chia Wei

AU - Yung, Ming Chi

AU - Hsu, Chuan Chih

AU - Liu, Ting Yu

N1 - Funding Information: This research and the APC was funded by the Ministry of Science and Technology, Taiwan (MOST 108-2218-E-002-010; MOST 107-2622-8-131-003; MOST 108-2622-E-131-002-CC3), and the industrial development bureau, Ministry of Economic Affairs of Taiwan (E10700010006-059, Conventional Industry Technology Development Plan). We are grateful to the staff of Technology Commons, College of Life Science, Nation Taiwan University (NTU) for help with transmission electron microscopy (TEM), and facilities support byWei-Bor Tsai and Ying-Chih Liao from the Department of Chemical Engineering, NTU. Publisher Copyright: © 2019 by the authors.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

AB - Environmental-friendly nanocomposite hydrogels of carboxymethyl-hexanoyl chitosan (CHC), graphene oxide (GO) and cellulose nanocrystals (CNCs) were combined to produce a bio-hydrogel with great biocompatibility and antibacterial ability. The size of the GO nanosheets was about 200-500 nm, and the CNCs had a length of 100-200 nm and a width of 10-20 nm, as shown by transmission electron microscopy (TEM). X-ray photoelectron spectroscopy (XPS) was utilized for the analysis of the oxygen functional groups of GO. The homogeneous dispersion of the CHC/GO/CNC nanocomposite hydrogel showed significantly higher water absorption capacity and water retention capability. In addition, inhibition of a variety of microorganisms (gram-negative and gram-positive bacteria and fungi) by the introduction of the CHC/GO/CNC nanocomposite hydrogel demonstrated that there is a great opportunity to use it in the bio-medical field, such as for plastic masks and wound dressings.

KW - Amphiphatic chitosan

KW - Antibacterial ability

KW - Cellulose nanocrystals

KW - Graphene oxide

KW - Nanocomposite hydrogel

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Preparation of amphiphilic chitosan-graphene oxide-cellulose nanocrystalline composite hydrogels and their biocompatibility and antibacterial properties

Abstract

Keywords

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