Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid

Yu Tsai Yang, Anthony J. Di Pasqua, Weiling He, Tsuimin Tsai, Katsuhiko Sueda, Yong Zhang, Michael Jay

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A penta-ethyl ester prodrug of the radionuclide decorporation agent diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was encapsulated in alginate beads by the ionotropic gelation method. An optimal formulation was found by varying initial concentrations of DTPA penta-ethyl ester, alginate polymer, Tween 80 surfactant and calcium chloride. All prepared alginate beads were ∼1.6 mm in diameter, and the optimal formulation had loading and encapsulation efficiencies of 91.0 ± 1.1 and 72.6 ± 2.2%, respectively, and only 3.2 ± 0.8% water absorption after storage at room temperature in ∼80% relative humidity. Moreover, Fourier transform infrared spectroscopy showed that DTPA penta-ethyl ester did not react with excipients during formation of the DTPA penta-ethyl ester-containing alginate beads. Release of prodrug from alginate beads was via anomalous transport, and its stability enhanced by encapsulation. Collectively, these data suggest that this solid dosage form may be suitable for oral administration after radionuclide contamination.

Original languageEnglish
Pages (from-to)1915-1920
Number of pages6
JournalCarbohydrate Polymers
Volume92
Issue number2
DOIs
Publication statusPublished - Feb 15 2013

Fingerprint

Alginate
Prodrugs
Esters
Acids
Encapsulation
Radioisotopes
Ionotropic gelation
Calcium Chloride
Calcium chloride
Polysorbates
Excipients
Dosage Forms
Water absorption
Surface-Active Agents
Fourier transform infrared spectroscopy
Atmospheric humidity
Polymers
Surface active agents
Contamination
alginic acid

Keywords

  • Alginate beads
  • Decorporation
  • Diethylenetriaminepentaacetic acid (DTPA)
  • Encapsulation
  • Oral drug delivery

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Yang, Y. T., Di Pasqua, A. J., He, W., Tsai, T., Sueda, K., Zhang, Y., & Jay, M. (2013). Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid. Carbohydrate Polymers, 92(2), 1915-1920. https://doi.org/10.1016/j.carbpol.2012.11.071

Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid. / Yang, Yu Tsai; Di Pasqua, Anthony J.; He, Weiling; Tsai, Tsuimin; Sueda, Katsuhiko; Zhang, Yong; Jay, Michael.

In: Carbohydrate Polymers, Vol. 92, No. 2, 15.02.2013, p. 1915-1920.

Research output: Contribution to journalArticle

Yang, YT, Di Pasqua, AJ, He, W, Tsai, T, Sueda, K, Zhang, Y & Jay, M 2013, 'Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid', Carbohydrate Polymers, vol. 92, no. 2, pp. 1915-1920. https://doi.org/10.1016/j.carbpol.2012.11.071
Yang, Yu Tsai ; Di Pasqua, Anthony J. ; He, Weiling ; Tsai, Tsuimin ; Sueda, Katsuhiko ; Zhang, Yong ; Jay, Michael. / Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid. In: Carbohydrate Polymers. 2013 ; Vol. 92, No. 2. pp. 1915-1920.
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